一 报告题目:Single cell analysis for early cancer detection
报告人:Tim H.-M. Huang, Ph.D(University of Texas Health Science Center)
报告时间:2014年10月21日(周二)上午8:30
报告地点:医学院行政楼四楼会议室
二 报告题目:The role of the motor protein KIF5B and the scaffolding protein JLP in proteasomal degradation of the oncoprotein c-MYC
报告人:Clement M. Lee, Ph.D( Ichan School of Medicine at Mount Sinai)
报告时间:2014年10月21日(周二)上午10:00
报告地点:医学院行政楼四楼会议室
报告摘要:
1) the motor protein KIF5B transports the oncoprotein c-MYC for the proteasomal degradation in the cytoplasm;
2) the scaffolding protein JLP tethers KIF5B and c-MYC to form a ternary complex and the complex is involved in transporting c-MYC for the proteasomal degradation;
3) KIF5B determines the subcellular localization of the complex;
4) KIF5B and JLP regulate c-MYC degradation and c-MYC-mediated transformation.