一、基本信息

葛高原，男，1986年11月出生，医学博士，硕士生导师，扬州大学附属医院心血管内科，邮箱：gyge@yzu.edu.cn。

二、教育经历

2004.9—2009.7，南华大学，医学院，临床医学专业，学士

2010.9—2013.6，南京医科大学，第一临床学院，内科学专业，硕士

2021.9—2024.6，南京医科大学，第一临床学院，内科学专业，博士

三、研究方向

主要从事心脏电生理与起搏的相关研究。

四、承担项目

1. 国家自然科学基金面上基金项目“心力衰竭心肌肌钙蛋白I变化致RCAN3解抑制CaN-NFAT的机制研究”项目号81170220，2012/01-2016/12，55万，参与。

2. 国家自然科学基金面上基金项目“Notch1修复心脏瓣膜内皮损伤和主动脉瓣狭窄发病机制的研究”项目号81170212，2012/01-2016/12，65万，参与。

3. 扬州市基础研究计划（联合专项）卫生健康类项目“MGST1在扩张型心肌病中作为关键调节因子参与纤维化的作用及机制”项目号2024-4-10，2万，主持。

4. 扬州市重点研发项目（社会发展）“金合欢素通过抑制心肌细胞自噬改善压力超负荷心脏重构的作用及机制研究”项目号YZ2024114，1万，主持。

5. 江苏省卫生健康委科研项目“金合欢素通过USP10调控心肌细胞自噬改善心脏重构的作用及机制研究”项目号Z2024068，2万，主持。

五、代表性论著

1.Ge, G., Wu, H., Xiong, F., Zhang, Y., Guo, Z., Bian, Z., Xu, J., Gu, C., Gu, N., Chen, X., & Yang, D. The cytotoxicity evaluation of magnetic iron oxide nanoparticles on human aortic endothelial cells. Nanoscale research letters,2013,8(1), 215.

2. Hu, F., Wang, Y., Gong, K.,Ge, G., Cao, M., Zhao, P., Sun, X., & Zhang, Z. Protective effects of drag-reducing polymers on ischemic reperfusion injury of isolated rat heart. Clinical hemorheology and microcirculation,2016,62(1), 1–11.

3. Gu, C., Wu, H.,Ge, G., Li, X., Guo, Z., Bian, Z., Xu, J., Lu, H., Chen, X., & Yang, D. In Vitro Effects of Hollow Gold Nanoshells on Human Aortic Endothelial Cells. Nanoscale research letters,2016,11(1), 397.

4. Yu, Y., Wu, T., Lu, Y., Zhao, W., Zhang, J., Chen, Q.,Ge, G., Hua, Y., Chen, K., Ullah, I., & Zhang, F. Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling. Free radical biology & medicine,2022,193(Pt 1), 108–121.

5. Lu, Y., Chen, K., Zhao, W., Hua, Y., Bao, S., Zhang, J., Wu, T.,Ge, G., Yu, Y., Sun, J., & Zhang, F. Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats. Journal of nanobiotechnology,2023, 21(1), 421.

6. Ge, G., Bo, D., Jiang, R., Zhao, W., & Lu, Y. Oral anticoagulants increased 30-day survival in sepsis patients complicated with atrial fibrillation: a retrospective analysis from MIMIC-IV database. Frontiers in cardiovascular medicine,2024,11, 1322045.

7. Ge, G., Bo, D., Zhang, F., & Yang, D. Non-Linear Association between Obstructive Sleep Apnea Risk and Lipid Profile: Data from the 2015-2018 National Health and Nutrition Examination Survey. Reviews in cardiovascular medicine,2024,25(5), 175.

8. Wu, T., Lu, Y., Yu, Y., Hua, Y.,Ge, G., Zhao, W., Chen, K., Zhong, Z., & Zhang, F. Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response. Cellular and molecular life sciences : CMLS,2024, 81(1), 432.

9. Ge, G., Zhao, W., Zhong, Z., Huang, Y., Hua, Y., Chen, K., Yu, Y., Wu, T., Lu, Y., Yadav, N., & Zhang, F. Acacetin ameliorates pressure overload-induced cardiac remodeling by targeting USP10 and inhibiting maladaptive cardiomyocyte autophagy. Phytomedicine : 2025;141:156588

10. Zhao, D., Dong, Y., Chen, Q.,Ge, G., Yadav, N., Yang, D., & Zhang, F. (2025). The impact of left atrial voltage abnormality on ablation outcomes in paroxysmal atrial fibrillation and its pre-procedural predictors: an observational retrospective study. The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 77(1), 77. 

六、获奖情况

1. 2024年扬州大学附属医院第五期扬帆计划培养对象；

2. 2020年江苏省事业单位工作人员嘉奖；

3. 2020年扬州市优秀农工党党员；

4. 2020年扬州大学疫情防控工作先进个人；