一、基本信息

顾雪峰，男，1976年10月出生，主任医师，博士研究生学历，医学博士学位，硕士生导师，本科毕业于东南大学医学院（原南京铁道医学院）临床医学专业，硕士毕业于江西中医药大学（原江西中医学院）中西医结合临床专业，博士毕业于东南大学内科学专业。曾在南京市第二医院、昆山市第一人民医院、无锡市第五人民医院工作。目前任职江苏省人民医院句容分院中心实验室主任、感染性疾病科科副主任。

江苏省中西医结合学会第一届、第二届、第三届感染病专业委员会委员;江苏省医院协会第五届传染病医院分会委员。

邮箱：sani666@163.com;guxuefeng@seu.edu.cn。

二、研究方向

主要从事肝病的基础与临床相关研究

三、承担项目

1. 2024年镇江市科技计划（社会发展）面上项目“RUSC1-AS1靶向PTBP1调控p53转录活性并激活Wnt/PCP途径影响乙肝相关性肝癌侵袭转移和化疗药物敏感性”，2024/08-2026/07，4万，主持。

2. 2024年江苏省人民医院句容分院人才引进专项基金项目“肝病的基础与临床”，2024/03-2026/03，30万，主持。

四、代表性论著

1．Gu XF*, Wei Y, Shen D, Mao Y. Construction of a prognostic model for disulfidptosis‑related long noncoding RNAs in R0 resected hepatocellular carcinoma and analysis of their impact on malignant behavior. BMC Cancer. 2024, 24(1):1068.

2．Gu XF*, Wei YY , Lu M, Huang J, Shen D, Wu X. Systematic Analysis of Disulfidptosis-Related lncRNAs in hepatocellular carcinoma with Vascular Invasion Revealed that AC131009.1 can Promote HCC Invasion and Metastasis through epithelial-mesenchymal transition. ACS Omega. 2024, 9(50):49986-49999.

3．Shi CB, Sun YT, Zhang Z,Gu XF*. A new cuproptosis-related lncRNAs model for predicting the prognosis of hepatitis B virus-associated hepatocellular carcinoma and experimental validation of cuproptosis-relatedlncRNA LINC01269. Int J Gen Med. 2024:17:6009–6027.（通讯作者）

4．Gu XF*, Sha L, Zhang S, Shen D, Zhao W, Yi Y. Neutrophils and lymphocytes can help distinguish asymptomatic COVID-19 from moderate COVID-19. Front Cell Infect Mi. 2021, 11:654272.

5．Gu XF*, Li H, Sha L, Zhao W. A prognostic model composed of four long noncoding RNAs predicts the overall survival of Asian patients with hepatocellular carcinoma. Cancer Med, 2020, 9(16): 5719-5730.

6．Gu XF*, Li H, Sha L, Zhao W. Construction and Comprehensive Analyses of a Competing Endogenous RNA Network in Tumor-Node-Metastasis Stage I Hepatocellular Carcinoma. Biomed Res Int, 2020, 2020: 5831064.

7．Gu XF*, Li H, Sha L, Zhao W. CELSR3 mRNA expression is increased in hepatocellular carcinoma and indicates poor prognosis. PeerJ, 2019, 7: e7816.

8．Gu XF*, Mao Y, Shi C, ..., Zhao W. MAGEC2 Correlates With Unfavorable Prognosis And Promotes Tumor Development In HCC Via Epithelial-Mesenchymal Transition. OncoTargets Ther, 2019, 12: 7843-7855.

9．Gu XF*, Shi C, Zhao W. Prognostic value of carbonic anhydrase XII (CA XII) overexpression in hepatocellular carcinoma. Int J Clin Exp Pathol, 2019;12(6):2173-2183.

10．Gu XF*, Mao Y,GeZJ, ......,ZhuJ. High expression of MAGE-A9 correlates with unfavorable Survival in hepatocellular carcinoma. Sci Rep. 2014, 4:6625.

11：Gu XF*, Mao Y, DingYQ, ...,ZhuJ. TIMP-3 Expression Associates with Malignant Behaviors and Predicts Favorable Survival in HCC. PLoS One. 2014, 9(8):e106161.

12．YangJ,FuMY,DingYQ, ...,Gu XF*. High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer. Dis Markers. 2014,2014:218968.（通讯作者）

13．FuMY, Wan F,PuXL, ...,Gu XF*. Elevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer. Int J Clin Exp Pathol. 2013, 6(10):2185-91.（通讯作者）

14：XuJQ,YangS,Gu XF*, ...,WangJ. SPARC correlates with unfavorable outcome and promotes tumor growth in lung squamous cell carcinoma. Exp Mol Pathol. 2019, 110:104276.（共同第一作者）

15:FuMY, Gu XF*,NiHH,...,BaoJ.High expression of inositol polyphosphate phosphatase-like 1 associates with unfavorable survival in hepatocellular carcinoma.Int J Clin Exp Pathol. 2013, 6(11):2515-22.（共同第一作者）