一、基本信息

姜子瑜，男，1983年09月出生，医学博士，博士后，副主任中医师，硕士生导师，灌南县第一人民医院，邮箱：Johnnyfly528@163.com。

二、教育经历

2002.09—2009.07，南京中医药大学，中西医结合临床专业，硕士

2009.09—2012.07，南京中医药大学，中西医结合临床专业，博士

三、研究方向

主要从事中医药抗恶性肿瘤的基础和临床研究

四、承担项目

1. 国家自然科学基金青年基金项目“基于内质网应激的β-榄香烯干预NSCLC细胞自噬稳态平衡作用及机制研究”，项目号81503306，2016/01-2018/12，21.6万，主持

2. 国家自然科学基金面上基金项目“基于Akt/mTOR/p70S6K通路探讨β-榄香烯诱导外泌体来源的miR-127调控肺癌细胞自噬的机制研究”，项目号81973525，2020/01-2023/12，55万，主持

五、代表性论著

1.Jiang Z, Jacob J, Sanka Loganathachetti D, Nainangu P and Chen B.β-elemene: Mechanistic studies on cancer cell interaction and its chemosensitization effect. Frontiers in pharmacology.2017, 8:105.（IF 5.810）

2.Liu Y,Jiang ZY（共同第一）, Zhou YL, Qiu HH, Wang G, Luo Y, Liu JB, Liu XW, Bu WQ, SongJ, Cui L, Jia XB, Feng L. β-elemene regulates endoplasmic reticulum stress toinduce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway. Biomedicine & Pharmacotherapy. 2017,93:490-497.（IF6.529）

3.刘静冰,刘雄伟,吴夏慧,步伟全,姜子瑜（通讯作者）. β-榄香烯通过抑制PI3K/AKT/mTOR信号通路诱导A549细胞发生保护性自噬研究[J].肿瘤药学, 2018, 8(1): 12 -16.）

4．Jiang Z, Jacob JA, Li J, Wu X, Wei G, Vimalanathan A, Mani R, Nainangu P,Rajadurai UM, Chen B. Influence of diet and dietary nanoparticles on gutdysbiosis. Microb Pathog. 2018, 118: 61- 65.（IF 3.738）

5.Jiang Z, Shan K, Song J, Liu J, Rajendran S, Pugazhendhi A, Jacob JA, Chen B. Toxic effects of magnetic nanoparticles on normal cells and organs. Life Science. 2019, 220: 156- 161.（IF 5.037）

6.Ziyu Jiang, Jingbing Liu, Baoan Chen, Rajesh Mani, Arivalagan Pugazhendhi, Joe Antony Jacob.Cytotoxic effects of a sesquiterpene β-elemene on THP-1 leukemia cells is mediated via crosstalk between beclin-1 mediated autophagy and caspase-dependent apoptosis. Process Biochemistry, 2019, 87: 174- 178.（IF 3.757）

7.吴秋兰,曹雯,王伟,姜子瑜（通讯作者）,陈莉,李丽丽.腕踝针配合阿片类药物治疗难治性癌痛:随机对照研究[J].中国针灸, 2019, 10: 1051- 1054.（中文核心）

8.Hui Huang, Kuizhong Shan, Jingbing Liu, Xiaoxin Tao, Sivalingam Periyasamy, Siva Durairaj,Ziyu Jiang（通讯作者）, Joe Antony Jacob. Synthesis, optimization and characterization of silver nanoparticles using the catkin extract of Piper longum for bactericidal effect against food-borne pathogens via conventional and mathematical approaches. Bioorganic Chemistry, 2020, 103: 104230. (IF 5.275)

9. Chao Jiang,Ziyu Jiang（共同第一）, Siyao Zhu, Jessima Amulraj, Vijay Kumar Deenadayalan, Joe Antony Jacob, Jun Qian. Biosynthesis of silver nanoparticles and the identification of possible reductants for the assessment of in vitro cytotoxic and in vivo antitumor effects. Journal of Drug Delivery Science and Technology, 2021, 63, 102444. (IF3.981)

10.Ziyu Jiang, Lingchang Li, Jianan Chen, Guoli Wei, Yi Ji, Xi Chen, Jingbing Liu, Jiege Huo. Human gut-microbiome interplay: Analysis of clinical studies for the emerging roles of diagnostic microbiology in inflammation, oncogenesis and cancer management. Infection, Genetics and Evolution, 2021, 93, 104946. (IF 3.342)

11.郑侠,姜子瑜（通讯作者）.基于癌症基因组图谱数据库分析miR-148a-3p在肝细胞癌中的表达和预后意义[J].肿瘤综合治疗电子杂志,2021,7(04):52-57.

12.陈嘉楠,丁文龙,朱思遥,姜子瑜（通讯作者）,刘静冰,李灵常.贝伐珠单抗治疗恶性腹腔积液的研究进展[J].临床肿瘤学杂志,2022,27(02):172-177.（科技核心）

13.Jiang Z,He Y, Ding W, Zhu S, Li Q, Sun X, Bian M, Huo J. Exosomes as Nanocarriers for Theragnostic miRNA Markers in Nonsmall Cell Lung Cancer Therapy. Journal of Nanomaterials, 2022: 8402500. (IF 2.98)

14.Jun Bao,Ziyu Jiang(共同第一), Wenlong Ding, Yuepeng Cao, Liu Yang, Jingbing Liu. Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells. Nanotechnology Reviews, 2022, 11(1), 1911-1926.(IF 7.85)

15.Jingbing Liu, Guanzheng Lu, Can Liang, Yifan Tian,Ziyu Jiang(通讯作者). Roles of anoikis in colorectal cancer therapy and the assessment of anoikis-regulatory molecules as therapeutic targets. Pathology Research and Practice, Volume 241, 2023,154256. (IF 3.31)

16.田一凡,李丽丽,梁粲,姜子瑜（通讯作者）.针灸防治化疗后骨髓抑制的研究进展[J].中医肿瘤学杂志,2023,5(04):81-85.（科技核心）