一、基本信息

陈炜炜，女，1984年01月出生，医学博士、博士后，扬州大学医学院副教授、副主任医师，硕士生导师。兼任国家自然科学基金委员会通讯评审专家、中国中药协会消化病药物研究专业委员会委员、中国民族医药学会脾胃病分会胰腺炎学组专家委员会常委、中华中医药学会脾胃病分会青年委员、中国中西医结合学会消化系统疾病专业委员会急性胰腺炎专家委员会青年委员等。2023年参与制定《急性胰腺炎中西医结合诊疗指南》。邮箱：18051062900@yzu.edu.cn

二、教育经历

1. 2012/09-2015/06，四川大学，华西临床医学院，中西医结合临床，博士

2. 2003/09-2010/07，成都中医药大学，针灸推拿学院，中医学（七年制针灸英语方向），本硕连读

三、研究方向

主要从事“胰腺损伤修复创新靶点筛选鉴定及药物开发”

四、承担项目

1. 国家自然科学基金面上项目：急性胰腺炎“祛瘀生新”新内涵：丹参酮IIA靶向MAOA介导巨噬细胞胞葬促进胰腺损伤修复的作用及机制（NO.82474309），2025/01-2028/12，48万，主持，在研

2. 国家自然科学基金青年基金：柴芩承气汤“攻伐热毒”调控PTX3-NLRP3-GSDMD轴抑制急性胰腺炎腺泡细胞焦亡的机制研究”（NO.82004291），2021/01-2023/12，24万，主持，已结题

3. 江苏省基础研究计划（自然科学基金）青年基金：急性胰腺炎胰腺坏死“PTX3-ROS热毒壅结”病机及验证（BK20190907），2019/07-2022/06，20万元，主持，已结题

4. 中国博士后科学基金面上资助：柴芩承气汤防治肥胖型急性胰腺炎胰腺坏死新机制（2018M632260），2018/06-2020/05，5万元，主持，已结题

5. 江苏省博士后日常资助计划及科研资助计划，2017/08-2019/07，18万元，主持，已结题

6. 扬州市自然科学基金青年基金：基于MAP3K5/MAPK信号通路研究柴芩承气汤抑制急性坏死性胰腺炎肠道细菌易位的机制（YZ2017106），2017/09-2019/08，2万元，主持，已结题

五、近5年代表性论著：第一及通讯作者（含共一及共通讯）

1. Wenyue Wang, Yaning Wang, Chenchen Yuan, Fei Cao, Weisong Tang, Qingtian Zhu, Xiaowu Dong, Lihui Deng, Guotao Lu, Qing Xia,Weiwei Chen. Pentraxin3 exacerbates acute pancreatitis injury by inhibiting oxidative phosphorylation pathway.Sci Rep. 2025 Feb 26;15(1):6977.

2. Tingting Wang, Fei Cao, Jiajun He, Lei Zhu, Xiaoxi Yang, Shuli Ma, Quping Zhu, Yuanhao Li, Chuting Yang, Jun, Liu, Chaowu Chen,Chen Weiwei. Visceral adiposity index as a key predictor of severity in acute pancreatitis - A large-scale retrospective cohort study.Rev Esp Enferm Dig. 2025 Feb 19.

3. Fei Cao, Jie Xiang, Yaodong Wang, Xijie Chen, Xirong Lu, Xingmeng Xu, Lin Chen, Yinghong Fan, Chenchen Yuan, Xiaowu Dong, Qingtian Zhu, Chenxia Han, Guotao Lu, Qing Xia,Weiwei Chen. Chaiqin chengqi decoction alleviates acute pancreatitis by targeting gasdermin D-mediated pyroptosis.J Ethnopharmacol. 2024 Jan 10;318(Pt A):116920.

4. Qian Zhang, Qingcheng Xu, Quping Zhu, Lei Zhu, Changbao Pan, Juan Chen, Jun Liu, Denghao Deng,Weiwei Chen, Chaowu Chen. Association between serum triglyceride level and severity of acute biliary pancreatitis.Pancreatology. 2024 Feb 6:S1424-3903(24)00028-0.

5. Xia Su, Shuli Ma, Xiaoxi Yang, Can Zhang,Weiwei Chen. Health Literacy Needs of Acute Pancreatitis Patients During the Diagnosis and Treatment Process Under the Lens of the Timing It Right Theory: A Qualitative Study.Patient Prefer Adherence. 2024 Feb 26:18:507-517.

6. Jianghua Zhao, Min Gu, Yu Zhang, Xiaoqin Jia, Weiming Xiao, Guotao Lu,Weiwei Chen, Weijuan Gong. Myeloid-derived suppressor cells in the tumor microenvironment reduce uncoupling protein 1 expression to boost immunosuppressive activity.Biochem Biophys Res Commun. 2024 Nov 5:732:150408.

7. Han F, Ding ZF, Shi XL, Zhu QT, Shen QH, Xu XM, Zhang JX, Gong WJ, Xiao WM, Wang D,Chen WW, Hu LH, Lu GT. Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice.Redox Biol. 2023 Aug;64:102787.

8. Ma S, Yang X, Xiang S, Lu G, Gong W,Chen W. Psychometric validation of the fear of progression questionnaire-short form in acute pancreatitis patients.Heliyon. 2023 Aug 19;9(8):e19060.

9. Zhu L, Yuan L, Wang T, Zhu Q, Zhang Q, Pan C, Xu Q, Deng D,Chen W, Chen J. Relation between triglycerides and the severity of acute pancreatitis combined with nonalcoholic fatty liver disease: a retrospective study.BMC Gastroenterol. 2023 Sep 14;23(1):313.

10. Ma S, Yang X, He H, Gao Y, Chen Y, Qin J, Zhang C, Lu G, Gong W,Chen W, Ren Y. The psychological experience of inpatients with acute pancreatitis: A qualitative study.BMJ Open. 2022 Jun 29;12(6):e060107.

11. Yang X, He J, Ma S, Wang T, Zhu Q, Cao F, Li Y, Yang C, Chen C, Lu G, Hu L, Liu J,Chen W. The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study.Lipids Health Dis. 2021 Nov 27;20(1):171.

12. Yang C, Wang T, Chen J, He J, Li Y, Chen C, Lu G,Chen W. Traditional Chinese Medicine Formulas Alleviate Acute Pancreatitis: Pharmacological Activities and Mechanisms.Pancreas. 2021 Nov-Dec 01;50(10):1348-1356.

13. Weiwei Chen, Chenchen Yuan, Yingying Lu, Qingtian Zhu, Xiaojie Ma, Weiming Xiao, Weijuan Gong, Wei Huang, Qing Xia, Guotao Lu, Weiqin Li. Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway.Oxid Med Cell Longev. 2020 Apr 8;2020:5390482.

六、获奖情况

1. 江苏省第六期“333高层次人才培养工程”第三层次培养对象

2. 江苏省第十六批“六大人才高峰”高层次人才

3. 扬州市“绿扬金凤计划”优秀博士人才