一、基本信息

孙海波，男，1981年5月出生，医学博士，教授，博士生导师，医学院（转化医学研究院），江南大学生物工程专业本科、南京医科大学硕士、博士学历。美国加州大学洛杉矶分校、美国西德斯西奈医学中心、美国加州大学旧金山分校博士后工作经历。曾任美国加州大学旧金山分校分子诊断实验室副医师专家和研发实验室负责人。现任扬州大学教授、美国癌症学会、美国免疫遗传学会会员。长期从事肿瘤分子和免疫靶向治疗研究，在国际著名杂志如Cancer Research、Clinical Cancer Research、Journal for ImmunoTherapy of Cancer, British Journal of Cancer等发表SCI研究论文25篇和国际会议论文8篇。以主要专利获权人获得国家发明专利两项。长期担任美国Advances in Modern Oncology Research杂志编辑和Oncogene、Molecular and Cellular Biochemistry等14个国际学术期刊的评审专家。曾于2017年荣获美国分子遗传学会“年度学者”奖（3/400+）。邮箱：frenksun@126.com。

二、教育经历

2006.9—2011.7，南京医科大学，基础医学院，病原生物学专业，博士

三、研究方向

1.肿瘤细胞免疫研究

1）肿瘤新抗原的筛选、鉴定和MHC I类抗原的递呈机制

2）基于受体-配体系统改造激活自然杀伤细胞

3）基于CAR改造自然杀伤细胞

2.肿瘤生物信息学

1）基于宏数据库的运算和分析

2）人源化单链抗体的预测

3）单细胞测序群组数据的融合与再提炼

4）结构蛋白质组学

3.肿瘤分子靶向研究

1）分子靶标的筛选、鉴定和分子机制

2）靶向分子靶标的抑制剂（小分子和单抗）的开发和应用研究

四、承担项目

国家自然科学基金面上项目“CREBBP蛋白通过转录/增强子景观重塑介导尤文肉瘤LSD1靶向治疗耐受的机制研究”项目号，2024/01-2027/12，49万，主持

五、代表性论著

1. Shiyi Yu, Ying Wang, Xue Gong, Zhehao Fan, Zheng Wang, Zhengyan Liang, Rui Wu, Binjie Cao, Ning Wang, Caili Bi, Dan Lv,Haibo Sun（通讯作者）. LncRNA AGPG Confers Endocrine Resistance in Breast Cancer by Promoting E2F1 Activity. [Journal Article].Cancer Researh, 2023.

2. Shiyi Yu, Zhengyan Liang, Zhehao Fan, Binjie Cao, Ning Wang, Rui Wu,Haibo Sun（通讯作者）. A Comprehensive Analysis Revealing FBXW9 as a Potential Prognostic and Immunological Biomarker in Breast Cancer. [Journal Article]. International journal of molecular sciences, 2023.

3. Bo Shi, Fei Ge, Liangliang Cai, Yi Yang, Xiaohui Guo, Rui Wu, Zhehao Fan, Binjie Cao, Ning Wang, Yue Si, Xinyue Lin, Weibing Dong,Haibo Sun（通讯作者）. Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma.[Journal Article].Frontiers in Immunology, 2023.

4. Ning Wang, Shilin Zhu, Dan Lv, Yajun Wang, Muhammad B Khawar,Haibo Sun（通讯作者）. Allosteric modulation of SHP2: Quest from known to unknown. [SCI]. Drug Design Development and Therapy, 2023.

5. Muhammad B Khawar, Guangzhong Gao, Mussarat Rafiq, Anila Shehzadi, Ali Afzal, Muddasir H Abbasi, Nadeem Sheikh, Nimra Afzal, Muhammad A Ashraf, Syeda E Hamid, Sara Shahzaman, Naseer Kawish,Haibo Sun（通讯作者）. Breaking down barriers: The potential of smarter CAR-engineered NK cells against solid tumors. [SCI]. Journal of Cellular Biochemistry, 2023.

6. Hai-Jian Sun, Fei Ge, Yue Si, Zheng Wang,Haibo Sun（通讯作者）. Importance of accurate diagnosis of congenital agenesis of the gallbladder from atypical gallbladder stone presentations: A case report. [SCI]. World Journal of Clinical Cases, 2023.

7. Binjie Cao, Haijian Sun, Zhehao Fan, Muhammad Babar Khawar, Liangliang Cai, Shiyi Yu, Zhengyan Liang, Dan Lv, Ning Wang, Caili Bi,Haibo Sun（通讯作者）. Integrative analyses of bulk microarray data to discover genes, pathways, and immune infiltration characteristics associated with targeting of Ewing sarcoma. [Journal Article]. Journal of Cancer Research and Clinical Oncology, 2023.

8. Muhammad Babar Khawar, Yajun Wang, Aneeqa Majeed, Ali Afzal, Kabeer Haneef,Haibo Sun（通讯作者）. Mini-organs with big impact: Organoids in liver cancer studies. [SCI]. Oncol Res, 2023.

9. Muhammad Babar Khawar, Fei Ge, Ali Afzal,Haibo Sun（通讯作者）. From barriers to novel strategies: smarter CAR T therapy hits hard to tumors. [SCI]. Frontiers in Immunology, 2023.

10. Dan Lv, Muhammad Babar Khawar, Zhengyan Liang, Yu Gao,Haibo Sun（通讯作者）. Neoantigens and NK Cells: "Trick or Treat" the Cancers? [SCI]. Frontiers in Immunology, 2022.

11. Haibo Sun, Tomas G. Martin, Jeffrey L. Wolf, Jeffrey M. Venstrom,Marielle Chiron, Sandrine Macé,Jonathon Keats, Denice Kong, John Marra. Individualized genetic makeup that controls natural killer cell function influences the efficacy of Isatuximab immunotherapy in patients with multiple myeloma. [Journal Article]. Journal for Immuno Therapy of Cancer, 2021.

12. Haibo Sun（通讯作者）, De-Chen Lin, Qi Cao, Brendan Pang, David D Gae, Victor Kwan Min Lee, Huey Jin Lim, Ngan Doan, Jonathan W Said, Sigal Gery, Marilynn Chow, Anand Mayakonda, Charles Forscher, Jeffrey W Tyner, H Phillip Koeffler. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. [Journal Article]. Clinical Cancer Research, 2017.

13. Muhammad Babar Khawar andHaibo Sun（通讯作者）. CAR-NK Cells: From Natural Basis to Design for Kill. [SCI]. Frontiers in Immunology, 2021.

14. Zhengyan Liang, Muhammad Babar Khawar, Jingyan Liang andHaibo Sun（通讯作者）. Bio-Conjugated Quantum Dots for Cancer Research: Detection and Imaging. [SCI]. Frontiers in Oncology, 2021.

15. Haibo Sun（通讯作者）,De-Chen Lin, Qi Cao, Xiao Guo, Helene Marijon, Zhiqiang Zhao, Sigal Gery, Liang Xu, Henry Yang, Brendan Pang, Victor Kwan Min Lee, Huey Jin Lim, Ngan Doan, Jonathan W. Said, Peiguo Chu, Anand Mayakonda, Tom Thomas, Charles Forscher, Erkan Baloglu, Sharon Shacham, Raja Rajalingam and H. Phillip Koeff. CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling. [Journal Article]. Cancer Research, 2016.

16. Haibo Sun（通讯作者）,N Hattori, W Chien, Q Sun, M Sudo, G L E-Ling, L Ding, S L Lim, S Shacham, M Kauffman, T Nakamaki & H P Koeffler. KPT-330 has antitumour activity against non-small cell lung cancer. [Journal Article]. British Journal of Cancer, 2014.

17. J. R. Greenland,Haibo Sun,T. Chong, J. P. Singer, J. Kukreja, S. R. Hays, J. A. Golden, G. H. Caughey, J. M. Venstrom, R. Rajalingam, D. Calabrese. HLA mismatching favoring host-versus-graft NK cell activity via KIR3DL1 is associated with improved outcomes following lung transplantation. [Journal Article]. American Journal of Transplantation, 2017.

六、获奖情况

1.2017年美国免疫遗传学会“年度学者”奖；