一、基本信息

郑东辉，男，1968年10月出生，医学博士，教授，硕士生导师，扬州大学附属淮安医院，邮箱：zddwjj@126.com。

二、教育经历

1985.9-1990.7 南京医学院 临床医学专业 学士；

2002.9-2005.7 南京医科大学 内科学专业 硕士研究生；

2006.9-2009.7 南京医科大学 皮肤病与性病学专业 博士研究生。

三、研究方向

主要从事急、慢性肾损伤的临床及机制研究

四、承担项目

1. 国家自然科学基金“WWP1介导的KLF6泛素化修饰：肾脏纤维化的新机制”项目号：82170757，2022/01-2025/12，55万，主持

2. 国家自然科学基金“基于“药-自组装短肽-功能肽复合物”结构构建的区域靶向双药纳米 纤维对缺血再灌注肾损伤保护作用及机制”项目号：81670624，2017/01-2020/12，58万，主持

3. 国家自然科学基金“基于"失敏"机制构建的具有协同保护作用的靶向双药纳米微球对缺血性再灌注肾损伤的效果评价及机制研究”项目号：81270817，2013/01-2016/12，70万，主持

4. 江苏省第五期“333工程”科技项目“基于“药物小分子肽自组装”概念构建的主动靶向双药纳米纤维递药体系对缺血再灌注肾损伤保护效应的评价及机制研究”项目号：BRA2017238，2017/07-2019/07，20万，主持

五、代表性论著

1.An C, Chen X,Zheng D. Association between anemia and serum Klotho in middle-aged and older adults. BMC Nephrol. 2023 Feb 16;24(1):38

2. Zhong Y, Li X, Xie J, Zhang Y, Li H,Zheng D. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis. Open Med (Wars). 2023;18(1):20230736.

3. Li X, Zhong Y, Yue R, Xie J, Zhang Y, Lin Y, Li H, Xu Y,Zheng D. Inhibition of MiR-106b-5p mediated by exosomes mitigates acute kidney injury by modulating transmissible endoplasmic reticulum stress and M1 macrophage polarization. J Cell Mol Med. 2023 Oct;27(19):2876-2889.

4. Zhang Y, Ding X, Guo L, Zhong Y, Xie J, Xu Y, Li H,Zheng D. Comprehensive analysis of the relationship between xanthine oxidoreductase activity and chronic kidney disease. iScience. 2023 Jul 10;26(11):107332.

5. Hu X, Tang J, Yu H, Yang H, Lu X,Zheng D. Preparation of fish collagen and vancomycin microspheres based on microfluidic technology and its application in osteomyelitis. Front Bioeng Biotechnol. 2023;11:1249706.

6. Chen C, Gao H, Ou H, Kwok RTK, Tang Y,Zheng D, Ding D. Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases. J Am Chem Soc. 2022 Mar 2;144(8):3429-3441

7. Xu Y, Jiang W, Zhong L, Li H, Bai L, Chen X, Lin Y,Zheng D. circ-AKT3 aggravates renal ischaemia-reperfusion injury via regulating miR-144-5p /Wnt/β-catenin pathway and oxidative stress. J Cell Mol Med. 2022 Mar;26(6):1766-1775.

8. Xu M, Zhao M,Zheng D. Effect of IGF-1C domain-modified nanoparticles on renal ischemia-reperfusion injury in mice. Ren Fail. 2022;44(1):1376-1387

9. Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B,Zheng D, Chen M. Trends of incidence and prognosis of upper tract urothelial carcinoma. Bosn J Basic Med Sci. 2021 Oct 1;21(5):607-619

10. Xu Y, Li X, Li H, Zhong L, Lin Y, Xie J,Zheng D. Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R. J Cell Mol Med. 2021 Jun;25(11):4912-4921.

11. Bai L, Lin Y, Xie J, Zhang Y, Wang H,Zheng D. MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1. Hum Cell. 2021 Mar;34(2):383-393.

12. Chen H,Zheng D,Pan W, Li X, Lv B, Gu W, Machuki JO, Chen J, Liang W, Qin K, Greven J, Hildebrand F, Yu Z, Zhang X, Guo K. Biomimetic Nanotheranostics Camouflaged with Cancer Cell Membranes Integrating Persistent Oxygen Supply and Homotypic Targeting for Hypoxic Tumor Elimination. ACS Appl Mater Interfaces. 2021 May 5;13(17):19710-19725

13. Lu X, Dong J,Zheng D, Li X, Ding D, Xu H. Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats. Nanomedicine. 2020 Aug;28:102208

14. Lin Y, Zhong L, Li H, Xu Y, Li X,Zheng D. Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874. BMC Pharmacol Toxicol. 2020 Jul 22;21(1):52

15. Yong H, Fu J, Gao G, Shi H,ZhengD, Zhou X. MiR-34a suppresses the proliferation and invasion of gastric cancer by modulating PDL1 in the immune microenvironment. Mol Cell Probes. 2020 Oct;53:101601

16. Sun J, Wang J,Zheng D, Hu X. Advances in therapeutic application of CRISPR-Cas9. Brief Funct Genomics. 2020 May 20;19(3):164-174

17. Wang YG,Zheng DH, Shi M, Xu XM. T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis. J Med Genet. 2019 Jan;56(1):22-28

18. Xie J, Wang X, Zhang Y, Li H, Xu Y,Zheng D. The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus. BMC Endocr Disord. 2019 Aug 5;19(1):84

19. Li H, Yan Z, Xiong Q, Chen X, Lin Y, Xu Y, Bai L, Jiang W,Zheng D, Xing C. Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis. Carbohydr Polym. 2019 May 15;212:1-10

20. Tang X, Lyu Y, Xie D, Li A, Liang Y,Zheng D. Therapeutic Effect of Sorafenib-Loaded TPGS-b-PCL Nanoparticles on Liver Cancer. J Biomed Nanotechnol. 2018 Feb 1;14(2):396-403

21. Chen X, Sun J, Li H, Wang H, Lin Y, Hu Y,Zheng D. Curcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury. Cell Physiol Biochem. 2017;43(5):2143-2154

22. Mao D, Liu J, Ji S, Wang T, Hu Y,Zheng D, Yang R, Kong D, Ding D. Amplification of near-infrared fluorescence in semiconducting polymer nanoprobe for grasping the behaviors of systemically administered endothelial cells in ischemia treatment. Biomaterials. 2017 Oct;143:109-119

23. Xu Y, Zhang B, Xie D, Hu Y, Li HL, Zhong LL, Wang HW, Jiang W, Ke ZP,Zheng DH. Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorates kidney ischemia/reperfusion injury by inhibiting cell apoptosis and inflammation. Oncotarget. 2017 Jun 13;8(24):39547-39558

24. Xu Y, Gao AM, Ji LJ, Li X, Zhong LL, Li HL,Zheng DH. All-Trans Retinoic Acid Attenuates Hypoxia-Induced Injury in NRK52E Cells via Inhibiting NF-x03BA;B/VEGF and TGF-β2/VEGF Pathway. Cell Physiol Biochem. 2016;38(1):229-36

六、获奖情况

1. 江苏省有突出贡献的中青年专家

2. 江苏省中青年科技领军人才

3. 江苏省“卫生拔尖人才”

4. 江苏省卫健委医学新技术引进奖4项

5. 淮海科技奖一等奖4项