一、基本信息

吴克艳，女，1983年02月出生，医学博士，硕士生导师，扬州大学附属医院消化内科，邮箱：kywu@yzu.edu.cn。

二、教育经历

2002.9—2007.7，南京中医药大学，第一临床医学院，中医学专业，学士

2009.9—2012.7，扬州大学，医学院，中西医结合临床专业，硕士

2018.9—2022.7，扬州大学，医学院，中西医结合基础专业，博士

三、研究方向

主要从事胃肠动力疾病及急性胰腺炎的中西医结合诊治相关研究

四、承担项目

江苏省中医药面上项目基金项目“车前草及其主要有效成分靶向抑制PGAM5治疗急性胰腺炎胰腺坏死的临床转化研究”项目号151，2023/01-2025/12，10万，主持

五、代表性论著

1.Keyan Wu; Guanghuai Yao; Xiaolei Shi; Huan Zhang; Qingtian Zhu; Xinnong Liu; Guotao Lu; Lianghao Hu; Weijuan Gong; Qi Yang; Yanbing Ding ; Asiaticoside ameliorates acinar cell necrosis in acute pancreatitis via toll-like receptor 4 pathway, Molecular Immunology, 2021, 130(-): 122-132（第一作者）

2.Keyan Wu; Hua Xie; Zhilin Zhang; Zixian Li; Lin Shi; Wei Zhou; Jing Zeng; Zhen Tian; Yu Zhang; Yanbing Ding; Weigan Shen ; Emerin knockdown induces the migration and invasion of hepatocellular carcinoma cells by up-regulating the cytoplasmic p21, Neoplasma, 2022, 69(1): 59-70（第一作者）

3.Keyan Wu;Man Teng;Wei Zhou;Fanglin Lu;Yang Zhou;Jing Zeng;Jie Yang;Xinnong Liu;Yu Zhang;Yanbing Ding;Weigan Shen；Wogonin Induces Cell Cycle Arrest and Apoptosis of Hepatocellular Carcinoma Cells by Activating Hippo Signalling. Anticancer Agents Med Chem. 2022, 22: 1551-1560（第一作者）

4. Chenchen Yuan; Xingmeng Xu; Ningzhi Wang; Qingtian Zhu; Junxian Zhang; Weijuan Gong; Yanbing Ding; Weiming Xiao; Weiwei Chen; Guotao Lu; Guanghuai Yao; Jiajia Pan;Keyan Wu; Paeonol protects against acute pancreatitis by inhibiting M1 macrophage polarization via the NLRP3 inflammasomes pathway, Biochemical and Biophysical Research Communications, 2022, 600: 35-43（通讯作者）

5. Yemin Xu;Keyan Wu; Sen Han; Shizhen Ding; Guotao Lu; Zhijie Lin; Yu Zhang; Weiming Xiao;Weijuan Gong; Yanbing Ding; Bin Deng ; Astilbin combined with lipopolysaccharide induces IL-10-producing regulatory B cells via the STAT3 signalling pathway, Biomedicine & Pharmacotherapy, 2020,129: 110450（共同第一）

6. Wei Zhou, Jiachun Weng,Keyan Wu, Xiao Xu, Hui Wang, Jin Zhang,Chunxue Zhao, Jie Yang,Yu Zhang,Weigan Shen.. Silencing of TAZ inhibits the motility of hepatocellular carcinoma cells through autophagy induction. Cancer management and research, 2019,11, 8743–8753（共同第一）

7. Wu, D.,Wu, K., Zhu, Q., Xiao, W., Shan, Q., Yan, Z., Wu, J., Deng, B., Xue, Y., Gong, W., Lu, G., & Ding, Y. (2018). Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway. Mediators of inflammation, 2018（共同第一）

8. Xiao, W.,Wu, K., Yin, M., Han, S., Ding, Y., Qiao, A., Lu, G., Deng, B., Bo, P., & Gong, W. (2015). Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. Journal of immunotherapy (Hagerstown, Md. : 1997), 38(5), 167–184.（共同第一）