一、基本信息

陈超波，男，1982年01月出生，医学博士，副教授，硕士生导师，无锡市锡山人民医院，普外科；南京大学附属鼓楼医院博士后流动站：在站博后，邮箱：bobo-chen@163.com，bobo19820106@gmail.com.

二、教育经历

2001.6—2006.7，江苏大学医学院，临床医学专业，学士

2010.6—2013.12，南京大学医学院，临床医学专业，硕士（在职）

2018.1—2021.2，西班牙康普顿斯大学医学院，生物医学专业，博士

三、研究方向

主要从事肝胆外科疾病相关研究

四、承担项目

无锡市卫生健康委科研项目面上项目“环境肝毒性致癌物致肝细胞转分化促胆管癌变的新机制：JNK缺失诱导内质网持续性应激”，项目号：M202160，2022/01-2023/12，5万，主持

五、代表性论著

1、陈超波，胡海，蒋兆彦，胆囊切除与脂质代谢关系异常的研究进展[J].《同济大学学报》，2018,39（1）：18-22.

2、陈超波，胡伟东，仇毓东，腹腔镜胆总管探查取石并一期缝合治疗胆总管结石的疗效研究[J].《国际外科学杂志》，2018,45（2）：112-116.

3、Chen, C. B., Hu, W. D., Zhao, W. W., Gu, Y. Y., Hou, H. W., & Pan, Z. (2018).Laparoscopic hepatectomy for the treatment of Caroli's disease: a case report.Annals of surgical treatment and research,94(3), 162–165. https://doi.org/10.4174/astr.2018.94.3.162.

4、Chen, Y., Weng, Z., Liu, Q., Shao, W., Guo, W.,Chen, C., Jiao, L., Wang, Q., Lu, Q., Sun, H., Gu, A., Hu, H., & Jiang, Z. (2019).FMO3 and its metabolite TMAO contribute to the formation of gallstones.Biochimica et biophysica acta. Molecular basis of disease, 1865(10), 2576–2585. https://doi.org/10.1016/j.bbadis.2019.06.016.

5、Chen, C., Nelson, L. J., Ávila, M. A., & Cubero, F. J. (2019).Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link.Cells, 8(10), 1172. https://doi.org/10.3390/cells8101172.

6、Yang, Y., Shao, C., Zhang, W., Wang, G., Lu, D. C., Han, W., Wu, Z. S., &Chen, C. B.(2019).Omega-3 polyunsaturated fatty acids prevent progression of liver fibrosis and promote liver regeneration after partial hepatectomy in cirrhotic rats.European review for medical and pharmacological sciences, 23(22), 10151–10160. https://doi.org/10.26355/eurrev_201911_19585.（通讯作者）

7、陈超波，蒋兆彦，胆汁酸代谢与非脂肪性酒精性肝病[J].《外科理论与实践》，2019，24（4）：201-204.

8、C. Chen, L. Nelson, M. Avila, F. J. Cubero.Overexpression of c-Jun N-terminal Kinase-1 coincides with the acquisition of cholangiocytic markers in experimental cholangiocarcinoma.Journal of Hepatology.70(1), e581; DOI:https://doi.org/10.1016/S0618-8278(19)31163-6.

9、Manieri, E., Folgueira, C., Rodríguez, M. E., Leiva-Vega, L., Esteban-Lafuente, L.,Chen, C., Cubero, F. J., Barrett, T., Cavanagh-Kyros, J., Seruggia, D., Rosell, A., Sanchez-Cabo, F., Gómez, M. J., Monte, M. J., G Marin, J. J., Davis, R. J., Mora, A., & Sabio, G. (2020).JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma.Proceedings of the National Academy of Sciences of the United States of America, 117(28), 16492–16499. https://doi.org/10.1073/pnas.2002672117.

10、Cubero, F. J., Mohamed, M. R., Woitok, M. M., Zhao, G., Hatting, M., Nevzorova, Y. A.,Chen, C., Haybaeck, J., de Bruin, A., Avila, M. A., Boekschoten, M. V., Davis, R. J., & Trautwein, C. (2020).Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma.Hepatology communications, 4(6), 834–851. https://doi.org/10.1002/hep4.1495.

11、Colyn, L., Bárcena-Varela, M., Álvarez-Sola, G., Latasa, M. U., Uriarte, I., Santamaría, E., Herranz, J. M., Santos-Laso, A., Arechederra, M., Ruiz de Gauna, M., Aspichueta, P., Canale, M., Casadei-Gardini, A., Francesconi, M., Carotti, S., Morini, S., Nelson, L. J., Iraburu, M. J.,Chen, C., Sangro, B., … Avila, M. A. (2021).Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma.Hepatology(Baltimore, Md.), 73(6), 2380–2396. https://doi.org/10.1002/hep.31642

12、Hu W, Xu Z, Shen X, Gu Y, Dai Z, Chen J, Zhu Z, Zhou Y, Zhao W,Chen C.Accident-related hepatic trauma in a medical clinical center in eastern China: a cross-sectional study.BMC Surg. 2021 Jan 6;21(1):16. doi: 10.1186/s12893-020-01043-9. PMID: 33407367; PMCID: PMC7789588.（通讯作者）

13、Benedé-Ubieto, R., Estévez-Vázquez, O., Guo, F.,Chen, C., Singh, Y., Nakaya, H. I., Gómez Del Moral, M., Lamas-Paz, A., Morán, L., López-Alcántara, N., Reissing, J., Bruns, T., Avila, M. A., Santamaría, E., Mazariegos, M. S., Woitok, M. M., Haas, U., Zheng, K., Juárez, I., Martín-Villa, J. M., … Nevzorova, Y. A. (2021).An Experimental DUAL Model of Advanced Liver Damage.Hepatology communications, 5(6), 1051–1068. https://doi.org/10.1002/hep4.1698.

14、Wu, H.,Chen, C., Ziani, S., Nelson, L. J., Ávila, M. A., Nevzorova, Y. A., & Cubero, F. J. (2021).Fibrotic Events in the Progression of Cholestatic Liver Disease.Cells, 10(5), 1107. https://doi.org/10.3390/cells10051107（前三位共同一作）

15、He, C., Shen, W.,Chen, C., Wang, Q., Lu, Q., Shao, W., Jiang, Z., & Hu, H. (2021).Circadian Rhythm Disruption Influenced Hepatic Lipid Metabolism, Gut Microbiota and Promoted Cholesterol Gallstone Formation in Mice.Frontiers in endocrinology, 12, 723918. https://doi.org/10.3389/fendo.2021.723918

16、Chen, C.,Wu, H., Ye, H., Tortajada, A., Rodríguez-Perales, S., Torres-Ruiz, R., Vidal, A., Peligros, M. I., Reissing, J., Bruns, T., Mohamed, M. R., Zheng, K., Lujambio, A., Iraburu, M. J., Colyn, L., Latasa, M. U., Arechederra, M., Fernández-Barrena, M. G., Berasain, C., Vaquero, J., … Cubero, F. J. (2021).Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.Cancers, 14(1), 78. https://doi.org/10.3390/cancers14010078

17、Guo, F., Estévez-Vázquez, O., Benedé-Ubieto, R., Maya-Miles, D., Zheng, K., Gallego-Durán, R., Rojas, Á., Ampuero, J., Romero-Gómez, M., Philip, K., Egbuniwe, I. U.,Chen, C., Simon, J., Delgado, T. C., Martínez-Chantar, M. L., Sun, J., Reissing, J., Bruns, T., Lamas-Paz, A., Moral, M., … Nevzorova, Y. A. (2021).A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy.Cancers, 14(1), 192.https://doi.org/10.3390/cancers14010192

18、Hu, H., Shao, W., Liu, Q., Liu, N., Wang, Q., Xu, J., Zhang, X., Weng, Z., Lu, Q., Jiao, L.,Chen, C., Sun, H., Jiang, Z., Zhang, X., & Gu, A. (2022).Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion.Nature communications, 13(1), 252.https://doi.org/10.1038/s41467-021-27758-8

19、Ye H,Chen C, Wu H, et al.Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.Cell Death Dis.2022;13(2):143. Published 2022 Feb 10. doi:10.1038/s41419-022-04580-8。

20、陈超波, 仇毓东.基于分子机制的肝内胆管癌研究和诊疗进展[J]. 腹部外科, 35(4): 245-251.

六、获奖情况

1.2019年 欧洲EASL奖学金

2.2020年 欧洲e-COST协会交流学习奖学金

3.2022年度锡山区第一届“最美科技工作者”称号