一、基本信息

王志荣，男，1977年09月出生，医学博士，骨伤科主任医师，硕士生导师，张家港市中医医院，科教科主任，邮箱：wangzzr1@163.com。

二、教育经历

1996.9—2001.6，南京医科大学，第一临床医学学院，临床医学，学士

2005.9—2008.7，苏州大学，医学院，骨外科，硕士

2009.9—2016.12，苏州大学，医学院，骨外科，博士

三、研究方向

主要从事骨伤科、骨质疏松症、骨溶解、骨界面材料改性等相关基础及临床研究。

四、承担项目

1、国家自然科学基金面上项目“基于TET2介导的AMPK/PPARγ通路探讨补肾活血方调控成骨细胞干预骨质疏松症机制”，82074473，2021/01-2024/12，55万，主持

2、江苏省社发项目“基于“内分泌-骨轴”调控骨改建防治关节置换术后早期假体周围骨丢失策略的建立及临床应用”，BE2020666，2020/12-2023/06，130万，主持

3、江苏省基础研究计划（自然科学基金）面上项目“基于氧化应激阻抗探讨TET2调节成骨细胞增殖、分化及凋亡的作用机制”，BK20191201，2019/07-2022/06，10万，主持

4、江苏省第五期“333工程”科研项目“TET2阻抗氧化应激调节OB增殖、分化及凋亡的抗骨质疏松机制研究”，BRA2020129，7万，主持

5、苏州市第五批姑苏卫生人才培养项目“基于复杂骨水泥流体强化探讨灌注型椎弓根螺钉在骨质疏松椎体应用效能提升的系列研究”，GSWS2019074，2018/10-2021/06，30万，主持

6、张家港市卫生重点人才项目“补肾活血方调控PLC-γ2/IP3/Ca2+信号通路抑制骨细胞焦亡干预老年骨质疏松症的机制研究”，ZJGWSRC202002，2020/12-2023/11，30万，主持

五、代表性论著

1.Xiao Long#; Huang Yu#; Yang Yuhe#; Miao Zhiwei#; Zhu Jie; Zhong Mengdan; Feng Chencheng; Tang Wenkai; Zhou Jinhua*; Wang Lihong*; Zhao Xin*;Wang Zhirong*,Biomimetic cytomembrane nanovaccines prevent breast cancer development in the long term,Nanoscale.2021, 13(6) : 3594-3601.（通讯作者）

2.Rong Cai, Long Xiao, Meixiu Liu, Fengyi Du*,Zhirong Wang*. Recent advances in functional Carbon Quantum Dots for Antitumour.International Journal of Nanomedicine. 2021.Inpress.（通讯作者）

3.Cai R, Xiao L, Qiu J, Zhao L, Li Z, Ju H, Sun M, Zhu W,Wang Z*, Du F*. Fabrication of cerium doped carbon dots with highly radical scavenging activity alleviates ferroptosis-induced oxidative damage.Nanotechnology.2021 Jul 9;32(39).（并列通讯）

4.Rong Cai, Long Xiao, Miaomiao Zhang, Lulu Zhao, Jingjing Zhang, Fengyi Du*,Zhirong Wang*. Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging.IET Nanobiotechnology. 2021 May 15. doi: 10.1049/nbt2.12058.（通讯作者）

5.Xiao Long#; Zhong Mengdan#; Huang Yu; Zhu Jie; Tang Wenkai; Li Danyong; Shi Jiandong; Lu Aiqing; Yang Huilin; Geng Dechun*; Li Hong*;Wang Zhirong*,Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways,Aging (Albany NY),2020, 12(21), 21706-21729.（通讯作者）

6.Xiao Long #; Lin Jiayi#; Chen Ruoyu; Huang Yu; Liu Yu; Bai Jiaxiang; Ge Gaoran; Shi Xiaopeng; Chen Yong; Shi Jiandong; Lu Aiqing; Yang Huilin; Geng Dechun*;Wang Zhirong*, Sustained release of melatonin from GelMA liposomes reduced osteoblast apoptosis and improved implant osseointegration in osteoporosis,Oxidative Medicine and Cellular Longevity,2020(4), 1-20.（通讯作者）

7.Tang Wenkai#, Xiao Long#, Ge Gaoran#, Zhong Mengdan, Zhu Jie, Qin Jialin, Feng Chengcheng, Zhang Wenhao, Bai Jiaxiang, Zhu Xuesong, Wei Minggang, Geng Dechun*,Wang Zhirong*.Puerarin inhibits titanium particle‐induced osteolysis and RANKL‐induced osteoclastogenesis via suppression of the NF‐κB signaling pathway,Journal of Cellular and Molecular Medicine,2020, 24(20), 11972-11983.（通讯作者）

8.Zhirong Wang,Menglei Xu, Jiaxiang Bai, Gaoran Ge, Xiaobin Guo, Binqing Yu, Long Xiao, Dechun Geng*, Yuefeng Hao*, Vildagliptin reduced extracellular matrix degradation in human primary chondrocytes.Eur J Pharmacol.2019; 844: 49-55.

9.Zhenyang Hou#, Zhen Wang#, Yunxia Tao#, Jiaxiang Bai, Binqing Yu, Jining Shen, Houyi Sun, Long Xiao, Yaozeng Xu, Jun Zhou,Zhirong Wang*,Dechun Geng*, KLF2 regulates osteoblast differentiation by targeting of Runx2.Laboratory investigation.2019; 99(2):271-280.（并列通讯）

10.Zhirong Wang #, Wen Zhang #, Hao Xu, Aiqing Lu, Huilin Yang, Zong-Ping Luo*, Perfusion pressure of a new cannulating fenestrated pedicle screw during cement augmentation.Clin Biomech (Bristol, Avon).2018; 57:42-47.

11.Ye Gu#,Zhirong Wang#, Jiawei Shi#, Liangliang Wang#, Zhenyang Hou, Xiaobin Guo, Yunxia Tao, Xiexing Wu, Wei Zhou, Yu Liu, Wen Zhang, Yaozeng Xu, Huilin Yang*, Feng Xue*, Dechun Geng*, Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway.Cell Death Dis.2017; 8(6): e 2878.（并列第一作者）

12.Yunxia Tao#,Zhirong Wang#,Liangliang Wang#, Jiawei Shi, Xiaobin Guo, Wei Zhou, Xiexing Wu, Yu Liu, Wen Zhang, Huilin Yang, Qin Shi, Yaozeng Xu, Dechun Geng*, Downregulation of miR-106b attenuates inflammatory responses and joint damage in collagen-induced arthritis.Rheumatology.2017; 56(10): 1804-1813.（并列第一作者）

13.Xuanyang Hu#,Zhirong Wang#,Jiawei Shi#, Xiaobin Guo#, Liangliang Wang, Zichuan Ping, Yunxia Tao, Huilin Yang, Jun Zhou*, Yaozeng Xu*, Dechun Geng*, Lithium chloride inhibits titanium particle-induced osteoclastogenesis by inhibiting the NF-κB pathway.Oncotarget.2017; 8(48):83949-83961（并列第一作者）

14.Ke Ji#, Suchun Wang#, Wei Miao, Jingcheng Yu,Zhirong Wang*, Application of esophageal radiography technique in the treatment of herniation of cervical disc with radiofrequency thermocoagulation and target ablation.J Neurosurg Sci.2017（通讯作者）

15.Xuanyang Hu#, Zichuan Ping#, Minfeng Gan#, Yunxia Tao#, Liangliang Wang, Jiawei Shi, Xiexing Wu, Wen Zhang, Huilin Yang, Yaozeng Xu*,Zhirong Wang*, Dechun Geng*, Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway.Acta Biomater.2017; 48: 479-488.（并列通讯）

16.Zichuan Ping#, Xuanyang Hu#, Liangliang Wang#, Jiawei Shi#, Yunxia Tao, Xiexing Wu, Zhenyang Hou, Xiaobin Guo, Wen Zhang, Huilin Yang, Yaozeng Xu*,Zhirong Wang*, Dechun Geng*, Melatonin attenuates titanium particle-induced osteolysis via activation of Wnt/β-catenin signaling pathway.Acta Biomater.2017; 51: 513-525.（并列通讯）

17.Zichuan Ping#,Zhirong Wang#, Jiawei Shi#, Liangliang Wang, Xiaobin Guo, Wei Zhou, Xuanyang Hu, Xiexing Wu, Yu Liu, Wen Zhang, Huilin Yang, Yaozeng Xu*, Ye Gu*, Dechun Geng*, Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling.Acta Biomater.2017; 62: 362-371.（并列通讯）

18.Shijun Zhu#, Xuanyang Hu#, Yunxia Tao#, Zichuan Ping, Liangliang Wang, Jiawei Shi, Xiexing Wu, Wen Zhang, Huilin Yang, Zhikui Nie, Yaozeng Xu*,Zhirong Wang*, Dechun Geng*, Strontium inhibits titanium particle-induced osteoclast activation and chronic inflammation via suppression of NF-κB pathway.Sci Rep.2016; 6: 36251（并列通讯）

19.Zhirong Wang#, Genlin Wang #, Xuesong Zhu, Dechun Geng, Huilin Yang*, Interleukin-2 is upregulated in patients with a prolapsed lumbar intervertebral disc and modulates cell proliferation, apoptosis and extracellular matrix metabolism of human nucleus pulposus cells.Exp Ther Med.2015; 10(6): 2437-2443.

六、获奖情况

1.2021年江苏省老年医学临床技术应用研究项目带头人；

2.2020年苏州市医学新技术引进奖一等奖；

3.2020年张家港市卫生重点人才；

4.2020年苏州市“讲理想、比贡献”创新创业“双杯赛”创新杯；

5.2019年教育部科技进步奖一等奖；

6.2018年江苏省第五期“333高层次人才培养工程”第三层次培养对象；

7.2018年苏州市科技进步奖三等奖；

8.2017年江苏省医学新技术引进奖二等奖。