姓 名：蒋敬庭

职 称：教授

导师类型：博士生导师

电子邮箱：jiangjingting@suda.edu.cn

个人简介：

医学博士，教授，临床肿瘤学博士生导师、免疫学博士生导师，享受国务院政府特殊津贴，江苏省有突出贡献中青年专家，江苏省优秀科技工作者，江苏省五一创新能手，江苏省第一批卫生领军人才，江苏省“333高层次人才培养工程”第二层次培养对象。主要从事肿瘤免疫治疗工作，现任常州市第一人民医院副院长，江苏省肿瘤免疫治疗工程技术研究中心主任，兼苏州大学细胞治疗研究院院长。江苏省政协委员。

长期担任国家自然科学基金项目评审专家与精准医学研究重点研发计划评审专家。兼任中国医药生物技术协会常务理事、中国医药生物技术协会医药生物技术临床专业委员会副主任委员、中国医药质量管理协会细胞治疗质量控制与研究专业委员会副主任委员、江苏省免疫学会肿瘤免疫专业委员会主任委员，江苏省中西医结合学会检验医学专业委员会副主任委员。

研究方向：

肿瘤免疫治疗和肿瘤微环境基础及临床转化研究。构建肿瘤免疫治疗的技术平台，开创了肿瘤精准联合免疫治疗的新模式。以肿瘤免疫治疗和肿瘤微环境研究为特色和发展方向：优化免疫细胞治疗临床研究方案和提高细胞治疗效能与特异性；构建射频消融联合免疫卡控点干预的创新治疗平台；研发新型CAR-T、TCR-T细胞治疗技术及临床应用研究，推动肿瘤临床生物治疗发展。

主持国家级、省部级项目14项；获江苏省科技进步奖4项、江苏医学科技奖2项、江苏省医学新技术引进奖14项。其中，《胃肠道免疫微环境调控研究与肿瘤精准诊疗策略的建立》荣获江苏省科学技术奖一等奖。以第一作者或通讯作者身份发表SCI论文150篇，国家发明专利6项，出版医学专著5部。

主持省级以上科研项目：

1. 国家自然科学基金面上项目，81972869，RFA术后激活AIM2介导抗肿瘤免疫应答在肠癌肝转移治疗中的作用机制，2020/01-2023/12，55万元

2. 国家重点研发计划，2018YFC1313402，聚焦多靶点或者多疗法联用破解恶性实体瘤异质性的科学问题，建立有效抑制肿瘤复发的免疫细胞治疗新技术，2018/08-2021/06，324万元

3. 江苏省重点研发计划，BE2018645，CAR-T细胞治疗胃肠道肿瘤的关键技术及临床应用研究，2018/07-2021/06，200万元

4. 国家自然科学基金海外及港澳学者合作研究基金延续资助项目，31729001，危险信号IL-33抗肿瘤免疫机制和临床应用，2018/01-2021/12，180万元

5. 国家自然科学基金面上项目，31570877，共刺激信号TIM-1促进CD8⁺T细胞抗肿瘤免疫应答及其作用机制，2016/01-2019/12，70万元

6. 国家科技支撑计划，2015BAI12B12，免疫细胞联合化疗治疗肺鳞癌的多中心临床研究及新策略研发，2015/04-2017/12，49.65万元

7. 国家自然科学基金海外及港澳学者合作研究基金项目，31428005，危险信号IL-33在适应性肿瘤免疫应答中的作用研究，2015/01-2016/12，20万元

8. 江苏省科技厅工程技术研究中心建设项目，BM2014404，江苏省肿瘤免疫治疗工程技术研究中心，2014/01-2017/12，1500万元

9. 国家自然科学基金面上项目，81171653，B7-H4在胃癌肿瘤微环境中表达的临床意义与调控机制，2012/01-2015/12，58万元

10.江苏省“333工程”科研项目资助计划，BRA2013054，miR-181b调控胃癌细胞生物学行为与肿瘤耐药机制的研究，2013/06-2015/05，20万元

11.江苏省2013年度引进国外技术、管理人才项目，SY20133200001，胃癌早期诊断和治疗疗效判断的新技术，2013/12-2014/12，10万元

12.江苏省自然科学基金项目，BK2011246，B7-H4在胃癌肿瘤微环境中的表达及其调控机制，2011/07-2014/07，8万元

13.江苏省委组织部333工程项目，BRA2010037，B7-H4分子在胃癌肿瘤微环境中的作用及其临床意义，2010/04-2013/03，8万元

14.国家自然科学基金项目，30950022，B7-H4在胃癌中免疫逃逸机制及对CIK细胞治疗效果的影响研究，2010/01-2010/12，10万元

近期代表性论著（部分）：

1. Wenting He, Dachuan Zhang, Hong Liu, Tongbing Chen, Jun Xie, Lei Peng, Xiao Zheng, Bin Xu, Qing Li^*,Jingting Jiang^*. The High Level of Tertiary Lymphoid Structure Is Correlated With Superior Survival in Patients With Advanced Gastric Cancer[J]. Front Oncol, 2020,10:980.

2. Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu,Jingting Jiang^*. A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling[J]. Mol Cancer. 2019, 18: 47.

3. Zhuojun Zheng, Xiao Zheng, Yuandong Zhu, Xiaoyan Gu, Weiying Gu^*, Xiaobao Xie, Wenwei Hu^*,Jingting Jiang^*. miR-183-5p inhibits occurrence and progression of acute myeloid leukemia via targeting Erbin[J]. Mol Ther. 2019, 27(3): 542-558.

4. Yingjie Shao, Xing Song, Wenjie Jiang, Yuan Chen, Zhonghua Ning, Wendong Gu,Jingting Jiang^*. MicroRNA-621 Acts as a Tumor Radiosensitizer by Directly Targeting SETDB1 in Hepatocellular Carcinoma[J].Mol Ther. 2019, 27(2): 355-364.

5. Dachuan Zhang, Wenting He, Chao Wu, Yan Tan, Yang He, Bin Xu, Lujun Chen, Qing Li^*,Jingting Jiang^*. Scoring System for Tumor-Infiltrating Lymphocytes and Its Prognostic Value for Gastric Cancer[J]. Front Immunol, 2019,10:71

6. Xiaohui Rui,Yun Xu,Xiping Jiang, Wenfeng Ye, Yaqing Huang,Jingting Jiang^*. Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis[J]. Cell Death Dis. 2018, 9(12): 1175.

7. Xiao Zheng, Xing Song, Yingjie Shao, Bin Xu, Wenwei Hu, Qi Zhou, Lujun Chen, Dachuan Zhang, Changping Wu,Jingting Jiang^*. Prognostic role of tumor-infiltrating lymphocytes in esophagus cancer: a meta-analysis[J]. Cell Physiol Biochem. 2018;45:720-732.

8. Lujun Chen, Wensi Zhai, Xiao Zheng, Quanqin Xie, Qi Zhou, Min Tao, Yibei Zhu, Changping Wu,Jingting Jiang^*. Decreased IFIT2 expression promotes gastric cancer progression and predicts poor prognosis of the patients[J]. Cell Physiol Biochem. 2018;45:15-25.

9. Jing Yang, Xin Jin, Yingjie Shao, Yunqian Pan, Lewis Roberts, Jun Zhang, Haojie Huang^*,Jingting Jiang^*. Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression[J]. Sci Rep. 2017;7:43864.

10. Yun Xu, Lujun Chen, Bin Xu, Yuqi Xiong, Min Yang, Xiaohui Rui, Liangrong Shi, Changping Wu, Binfeng Lu^*,Jingting Jiang^*. Higher numbers of T-bet⁺ tumor-infiltrating lymphocytes associate with better survival in human epithelial ovarian cancer[J]. Cell Physiol Biochem. 2017;41:475-483.

11. Yaqing Huang, Yun Xu, Xiaodong Li, Xiaohui Rui, Xiping Jiang, Fenghua Zhang,Jingting Jiang^*. Treatment of recurrent epithelial ovarian carcinoma with singleagent apatinib[J]. Transl Cancer Res, 2017;6(1):261-268.

12. Jing Li, Lujun Chen, Yuqi Xiong, Xiao Zheng, Quanqin Xie, Qi Zhou, Liangrong Shi, Changping Wu, Haitao Wang^*,Jingting Jiang^*. Knock down of PD-L1 in human gastric cancer cells inhibits tumor progression and improves the cytotoxic sensitivity to CIK therapy[J]. Cell Physiol Biochem. 2017;41:907-920.

13. Yanjie Xu, Jianping Chen, Cao Gao, Danxia Zhu, Xiaoli Xu, Changping Wu^*,Jingting Jiang^*. MicroRNA‑497 inhibits tumor growth through targeting insulin receptor substrate 1 in colorectal cancer[J]. Oncology Letters. 2017; 14: 6379-6386.

14. Yingjie Shao, Wendong Gu, Zhonghua Ning, Xing Song, Honglei Pei,Jingting Jiang^*.Evaluating the prognostic value of microRNA-203 in solid tumors based on a meta-analysis and the Cancer Genome Atlas (TCGA) datasets[J]. Cell Physiol Biochem. 2017;41:1468-1480.

15. Xing Song, Yang Han, Yingjie Shao, Wendong Gu, Honglei Pei^*,Jingting Jiang^*. Assessment of local treatmentmodalities for FIGO stage IB-IIB cervical cancer: A propensity-score matched analysis based on SEER database[J]. Sci Rep. 2017;7(1):3175.

16. Wenwei Hu, Xiaodong Li, Qing Li, Yan Tan, Bin Xu, Quanqin Xie, Xu Deng, Binfeng Lu,Jingting Jiang^*, Changping Wu^*. Interleukin-33 expression does not correlate with survival of gastric cancer patients[J].Pathol Oncol Res. 2017;23(3):615-619.

17. Lujun Chen, Yuqi Xiong, Jing Li, Xiao Zheng, Qi Zhou, Abbey Turner, Changping Wu, Binfeng Lu^*,Jingting Jiang^*. PD-L1 expression promotes epithelial to mesenchymal transition in human esophageal cancer[J]. Cell Physiol Biochem. 2017;42(6):2267-2280.

18. Liangrong Shi, Lujun Chen, Changping Wu^*, Yibei Zhu, Bin Xu, Xiao Zheng, Mingfen Sun, Wen Wen, Xichao Dai, Min Yang, Quansheng Lv, Binfeng Lu^*,Jingting Jiang^*. PD-1 blockade boosts radiofrequency ablation-elicited adaptive immune responses against tumor[J]. Clin Cancer Res. 2016;22(5):1173-1184.

19. Qi Zhou, Xiao Zheng, Lujun Chen, XinYang,Jingting Jiang^*, Changping Wu^*. Smad2/3/4 pathway contributes to TGF-β-Induced miRNA-181b expression to promote gastric cancer metastasis by targeting Timp3[J]. Cell Physiol Biochem. 2016;39(2):453-466.

20. Yingjie Shao, Yiting Geng, Wendong Gu, Zhonghua Ning, Jin Huang, Honglei Pei,Jingting Jiang^*. Assessment of lymph node ratio to replace the pN categories system of classification of the TNM system in esophageal squamous cell carcinoma[J]. J Thorac Oncol. 2016,11(10):1774-1784.

21. Zhuojun Zheng, Xiaodong Li, Yuandong Zhu, Weiying Gu, Xiaobao Xie,Jingting Jiang^*. Prognostic significance of miRNA in patients with diffuse large B-Cell lymphoma: a meta-analysis[J]. Cell Physiol Biochem. 2016;39(5):1891-1904.

22. Xiaodong Li, Xichao Dai, Liangrong Shi, Yong Jiang, Xuemin Chen, Lujun Chen, Jiemin Zhao, Weiguang Qiang, Jun Wu, Mei Ji,Jingting Jiang^*, Changping Wu^*. Phase II/III study of radiofrequency ablation combined with cytokine-Induced killer cells treating colorectal liver metastases[J]. Cell Physiol Biochem. 2016;40(1-2):137-145.

23. Peng Du, Ruihua Xiong, Xiaodong Li,Jingting Jiang^*. Immune regulation and antitumor effect of TIM-1[J]. Journal of Immunology Research. 2016:8605134. doi: 10.1155/2016/8605134.

24. Xiaodong Li, Xiao Zheng, Bin Xu, Dachuan Zhang, Yun Xu, Quanqin Xie, Wenwei Hu, Zhuojun Zheng, Yingjie Shao, Jun Wu, Mei Ji,Jingting Jiang^*, Changping Wu^*. Lower Bmi-1 expression may predict longer survival of colon cancer patients[J]. Cell Physiol Biochem. 2016;39(6):2421-2426.

25. Liangrong Shi, Xiaodong Li, Honglei Pei, Jiemin Zhao, Weiguang Qiang, Jin Wang, Bin Xu, Lujun Chen, Jun Wu, Mei Ji, Qicheng Lu, Zhong Li, Haitao Wang,Jingting Jiang^*,Changping Wu^*. Phase II study of computed tomography-guided 125I-seed implantation plus chemotherapy for locally recurrent rectal cancer[J]. Radiother Oncol. 2016; 118(2):375-381.

26. Yiting Geng, Yingjie Shao, Danxia Zhu, Xiao Zheng, Qi Zhou, Wenjie Zhou, Xuefeng Ni, Changping Wu^*,Jingting Jiang^*. Systemic immune-inflammation index predicts prognosis of patients with esophageal squamous cell carcinoma: a propensity score-matched analysis[J]. Sci Rep. 2016; 6:39482.

27. Juan Liu, Hui Wang, Jun Xie,Jingting Jiang^*. Nerve fbrolipoma with extensive calcifcation and ossifcation: a rare case report[J]. Int J Clin Exp Pathol 2016;9(2):2567-2570.

28. Zhonghua Ning, Zhigang Wang, Xiaodong Li, Lujun Chen, Bin Xu, Wendong Gu, Yingjie Shao, Yun Xu, Jin Huang, Honglei Pei^*,Jingting Jiang^*. Proposed modification of nodal staging as an alternative to the seventh edition of the American joint committee on cancer Tumor-Node-Metastasis staging system improves the prognostic prediction in the resected esophageal squamous-cell carcinoma[J]. J Thorac Oncol. 2015;10(7):1091-1098.

29. Yingjie Shao, Yiting Geng, Wendong Gu, Jin Huang, Honglei Pei^*,Jingting Jiang^*. Prognostic role of tissue and circulating microRNA-200c in malignant tumors: a systematic review and meta-analysis[J]. Cell Physiol Biochem. 2015;35(1):1188-1200.

30. Lujun Chen, Jun Chen, Bin Xu, Qi Wang, Wei Zhou, Guangbo Zhang, Jing Sun, Liangrong Shi, Honglei Pei, Changping Wu,Jingting Jiang^*.B7-H3 expression associates with tumor invasion and patient’s poor survival in human esophageal cancer[J]. Am J Transl Res 2015;7(12):2646-2660.

31. Yiting Geng, Yingjie Shao, Wenting He, Wenwei Hu, Yanjie Xu, Jun Chen, Changping Wu^*,Jingting Jiang^*. Prognostic role of tumor-infiltrating lymphocytes in lung cancer: a Meta-Analysis[J]. Cell Physiol Biochem. 2015;37(4):1560-1571.

32. Hui Wang, Jun Xie, Yan Tan, Jingting Jiang^*. Glomus tumor of the trachea: a rare case report[J].Int J Clin Exp Pathol 2015;8(8):9723-9726.

33. Yingjie Shao, Zhonghua Ning, Jun Chen, Yiting Geng, Wendong Gu, Jin Huang, Honglei Pei^*, Yueping Shen^*,Jingting Jiang^*. Prognostic nomogram integrated systemic inflammation score for patients with esophageal squamouscell carcinoma undergoing radical esophagectomy[J]. Sci Rep. 2015;5:18811.

34. Chen Wu, Yonggong Wang, Yang Xia, Shaohua He, Zhiqiang Wang, Yijiang Chen, Changping Wu, Yongqian Shu^*,Jingting Jiang^*. Wilms’ Tumor 1 Enhances Cisplatin-resistance of Advanced NSCLC.FEBS Letters[J]. 2014;588(24):4566-4572.

35. Xiaodong Li, Mei Ji, Xiao Zheng, Zhonghua Ning, Jun Wu, Binfeng Lu, Changping Wu^*,Jingting Jiang^*. Evaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors [J]. Journal of Translational Medicine. 2014; 11(1):215.

36. Jian Liu, Lujun Chen, Haifeng Deng, Bin Xu, Min Li, Xiao Zheng, Changping Wu,Jingting Jiang^*. Epithelial-to-mesenchymal transition in human esophageal cancer associates with tumor progression and patient’s survival [J]. Int J Clin Exp Pathol. 2014;7(10):6943-6949.

37. Hui Wang, Changqing Lu, Yan Tan, Jun Xie,Jingting Jiang^*. Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells [J]. Int J Clin Exp Pathol. 2014;7(9):5909-5915.

38. Juan Liu, Weifeng Shi, Jingfang Ju, Changping Wu,Jingting Jiang^*. miR-181b as a key regulator of oncogenic process and its clinical implications in cancer [J]. Biomedical Reports. 2014; 2(1):7-11.

39. Hongbing Shi, Mei Ji, Jun Wu, Qi Zhou, Xiaodong Li, Zhengguang Li, Xiao Zheng, Bin Xu, Weiqing Zhao, Changping Wu^*,Jingting Jiang^*. Serum B7-H4 expression is a significant prognostic indicator for patients with gastric cancer[J]. World J Surg Oncol. 2014;12(1):188.

40. Hui Wang, Changqing Lu, Qing Li, Jun Xie, Tongbing Chen, Yan Tan, Changping Wu^*,Jingting Jiang^*. The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells [J].Molecules and cells. 2014, 37(11):812-818

41. Lujun Chen, Xiao Zheng, Yueping Shen, Yibei Zhu, Qing Li, Junjun Chen, Rui Xia, Shuming Zhou, Changping Wu, Xueguang Zhang, Binfeng Lu^*,Jingting Jiang^*. Higher numbers of T-bet⁺ intratumoral lymphoid cells correlate with better survival in gastric cancer[J]. Cancer Immunol Immunother. 2013;62(3): 553-561.

42. Jingting Jiang^*, Changping Wu, Binfeng Lu^*. Cytokine induced killer T cells promote antitumor immunity [J]. Journal of Translational Medicine. 2013; 11(1):83.

43. Xiaodong Li, Changping Wu^*, Mei Ji, Jun Wu, Binfeng Lu, Hongbing Shi,Jingting Jiang^*. Characteristic analysis of α-fetoprotein-producing gastric carcinoma in China[J]. World Journal of Surgical Oncology. 2013;11:246.

44. Lujun Chen, Yahua Lu, Fengming Wang, Meng Zhou, Yang Chu, Wen׳ge Ding, Cuiping Liu, Jun Xie, Changping Wu^*,Jingting Jiang^*. Expression of co-stimulatory molecule B7-H4 in patients suffering from rheumatoid arthritis [J]. Immunology Letters. 2013;154(1-2):25-30.

45. Hongbing Shi, Mei Ji, Jun Wu, Qi Zhou, Xiaodong Li, Zhengguang Li, Xiao Zheng, Bin Xu, Haifeng Deng, Weiqing Zhao, Changping Wu^*,Jingting Jiang^*. Serum Lemur tyrosine kinase 3 expression in colorectal cancer patients predicts cancer progression and prognosis[J]. Medical Oncology. 2013;30:754.

46. Haijiao Yan, Wensong Liu, Wenhui Sun, Jun Wu, Mei Ji, Qi Wang, Bin Xu, Xiao Zheng,Jingting Jiang^*, Changping Wu^*. miR-17-5p inhibitor enhances chemosensitivity to gemcitabine via upregulating Bim expression in pancreatic cancer cells [J]. Digestive Diseases Sciences. 2012;57(12):3160-3167.

47. Xiaodong Li, Bin Xu, Jun Wu, Mei Ji, Beihua Xu,Jingting Jiang^*, Changping Wu^*. Review of Chinese clinical trials on CIK cell treatment for malignancies[J]. Clin Transl Oncol. 2012;14(5):242-245.

48. Liangrong Shi, Qi Zhou, Jun Wu, Mei Ji, Guojun Li,Jingting Jiang^*, Changping Wu^*. Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer[J]. Cancer Immunol Immunother. 2012;61(12):2251-2259.

49. Liangrong Shi, Changping Wu, Jun Wu, Wenjie Zhou, Mei Ji, Hongyu Zhang, Jiemin Zhao, Yuanquan Huang, Honglei Pei, Zhong Li, Jingfang Ju,Jingting Jiang^*. Computed tomography-guided permanent brachytherapy for locoregional recurrent gastric cancer[J]. Radiother Oncol. 2012;7:114-123.