王辉辉，女，1989年2月出生，工科博士，助理研究员，硕士生导师。2012年本科毕业于郑州大学，2017年10月博士毕业于中国科学院大连化学物理研究所。研究方向为新型纳米酶材料的开发及其在抗肿瘤、抗炎症性疾病领域中的应用研究。已在Nano Today、Small、Adv Healthcare Mater、Materials Today Nano、Advanced Materials Interfaces等国际高水平学术期刊上发表SCI论文十余篇，授权中国发明专利1项，参编英文专著《Nanomaterials for Tumor Targeting Theranostics》1部。欢迎药学、药剂学、中药学研究生报考。

近年来完成及正在进行的主要课题

1.国家自然科学基金青年项目，2025/01-2027/12，30万，主持

2.扬州市自然科学基金项目，2024/07-2026/06，10万，主持

3.江苏省高等学校基础科学自然科学面上项目，已结题，3万，主持

4.教育部重点实验室开放课题项目，已结题，5万，主持

近年来以第一作者和/或通讯作者发表的学术论文

1.Huihui Wang1#, Xueping Huang1#, Ran Gao, Ke Li, Dandan Li, Zhuobin Xu, Zemin Ling, Chun Pan*, Lizeng Gao*, Hao Chen*; Multifunctional artificial peroxisome basing on lactate oxidase as a self-cascade enhancing active oxygen amplifier for tumor therapy.ACS Appl. Mater. Interfaces.2025, 17, 7275.

2.Huihui Wang,Dongchuan Chu, Maolin Zhang, Xueping Huang, Yu Shi, Yi Zhao, Hang Qu, Dandan Li, Zhuobin Xu, Lizeng Gao*, Xing Zhang*, Wei Wang*; Manganese-doped carbon dots with catalase-like activity enable MRI-guided enhanced photodynamic therapy.Colloids and Surfaces B: Biointerfaces.2025, 246, 114398.

3. Wenzhen Bu, Yu Shi, Xueping Huang, Shang Wu, Letao Jiang, Chun Pan, Dandan Li, Zhuobin Xu,Huihui Wang*, Hao Chen* and Jianwei Du*; Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration.Journal of Nanobiotechnology.2024, 22, 412.

4. Yu Shi, Wenzhen Bu, Dongchuan Chu, Wenzheng Lin, Ke Li, Xueping Huang, Xinglong Wang, Yin Wu, Shang Wu, Dandan Li, Zhuobin Xu, Zhipeng Cao*, Hao Chen*,Huihui Wang*; Rescuing nucleus pulposus cells from ROS toxic microenvironment via mitochondria-targeted carbon dot-supported Prussian blue to alleviate intervertebral disc degeneration.Adv. Healthcare Mater.2024, 2300533. IF: 10

5. Dongchuan Chu, Hang Qu, Xueping Huang, Yu Shi, Ke Li, Wenzheng Lin, Zhuobin Xu, Dandan Li, Hao Chen*, Lizeng Gao*, Wei Wang* andHuihui Wang*; Manganese Amplifies Photo-induced ROS in Toluidine Blue Carbon Dots to Boost MRI guided Chemo/Photo-dynamic Therapy.Small.2023, 2304968. IF: 13.3

6. Wenzheng Lin, Sihan Hu, Ke Li, Yu Shi, Chun Pan, Zhuobin Xu, Dandan Li,

Huihui Wang,* Bin Li,* and Hao Chen*; Breaking Osteoclast-Acid Vicious Cycle to Rescue Osteoporosis via an Acid Responsive Organic Framework-Based Neutralizing and Gene Editing Platform.Small.2023, 2307595. IF: 13.3

7. Shang Wu, Yu Shi, Letao Jiang, Wenzhen Bu, Kai Zhang, Wenzheng Lin, Chun Pan,Zhuobin Xu, Jianwei Du*, Hao Chen*, andHuihui Wang*; N-Acetylcysteine-Derived Carbon Dots for Free Radical Scavenging in Intervertebral Disc Degeneration.Adv. Healthcare Mater.2023, 2300533. IF: 10

8.Huihui Wang^#, Yue Shen^#, Lei Chen^#, Ke Li, Yu Shi, Zhuobin Xu, Dandan Li, Hao Chen*, Wei Wang*, Lizeng Gao*; Enhancing catalase-like activity of Prussian blue nanozyme by gadolinium-doping for imaging-guided antitumor amplification via photodynamic therapy and chemotherapy.Materials Today Nano,2023, 22, 100326. IF: 10.3

9. Ke Li^#, Sihan Hu^#, Jinhua Huang^#, Yu Shi, Wenzheng Lin, Xiangyu Liu, Wenwen Mao, Chunbiao Wu, Chun Pan, Zhuobin Xu,Huihui Wang*, Lizeng Gao*, Hao Chen*; Targeting ROS-induced osteoblast senescence and RANKL production by Prussian blue nanozyme based gene editing platform to reverse osteoporosis.Nano today,2023, 50, 101839.IF: 17.4

10. Xinglong Wang; Gongke Li; Ke Li; Yu Shi; Wenzheng Lin; Chun Pan; Dandan Li; Hao Chen*; Jianwei Du*;Huihui Wang*; Controlled-release of apatinib for targeted inhibition of osteosarcoma by supramolecular nanovalve-modified mesoporous silica,Front Bioeng Biotech, 2023, 11(1135655) IF: 6.064

11.Huihui Wang,* Lu Cheng, Shang Ma, Liming Ding, Wei Zhang, Zhuobin Xu, Dandan Li, and Lizeng Gao.Self-assembled multiple enzyme composites for enhanced synergistic cancer starving-catalytic therapy.ACS Appl. Mater. Interfaces2020, 12, 20191−20201. IF: 9.5

12.Huihui Wang, Hao Wu, Hujun Shen, Shaote Geng, Beibei Wang, Yanfang Wang, Xiaojun Ma, Guohui Li and Mingqian Tan*,A bimodal MRI and NIR liposome nanoprobe for tumor targeted molecular imaging.J. Mater. Chem. B, 2015, 3, 8832-8841. IF: 7.571

13.Huihui Wang, Dongsheng Sun, Han Liao, Yanfang Wang, Shan Zhao, Ying Zhang, Guojun Lv, Xiaojun Ma, Yang Liua and Guangwei Sun. Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging.Talanta, 2017, 171, 8-15. IF: 6.556

授权发明专利

王辉辉、谭明乾、马小军、吕国军。肿瘤靶向核磁共振/荧光双模态成像造影剂及其制备和应用。已授权。授权号：CN 106390143 B。

联系方式

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