一、基本信息

龙聪，男，博士研究生学历，医学博士学位。

学科专业：临床检验诊断学

社会任职：1、泰州市医学会检验医学分会委员；2、泰州市健康管理学会检验医学分会副主任委员；3、江苏省研究型医院学会感染检验与合理用药专业委员会疑难感染性疾病快速诊断学组委员。

二、教育经历

1997.09~2002.06：武汉大学医学检验专业毕业

2008.09~2011.06：海军军医大学生物化学与分子生物学专业攻读硕士学位

2013.09~2016.06：武汉大学病原生物学专业攻读博士学位

2018.03~至今：靖江市人民医院检验科主任

三、研究方向

主要科学研究领域和兴趣：小分子化合物对肿瘤病毒编码的蛋白以及对肿瘤细胞生长的抑制的分子机制研究，以及Hsp90和疱疹病毒蛋白激酶相互作用的分子机制研究

四、代表性论著

[1] Long C, Guo W, Zhou H, Wang J, Wang H, Sun X. Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi’s sarcoma-associated herpesvirus-associated primary effusion lymphoma cells. International Journal of Oncology, 2016, 48(4): 1519-1530.

[2] Long C, Wang J, Guo W, Wang H, Wang C, Liu Y, Sun X. Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity protein 1 in primary effusion lymphoma cells. BiochemBiophys Res Commun, 2016, 469(1): 87-93.

[3] Zhou Y, Ma J, Zhang J, He L, Gong J,Long C. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70.Oncol Rep, 2017, 37(1): 313-322.

[4] Feng QQ, Dong ZQ, Zhou Y, Zhang H, Long C. miR-16-1-3p targets TWIST1 to inhibit cell proliferation and invasion in NSCLC. Bratisl Med, 2018, 119(1): 60–65.

[5] Zhou H, Guo W,Long C, Wang H, Wang J, Sun XTriptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1. Biochem Biophys Res Commun, 2015, 456(3): 815-820.

[6] Wang J, Guo W,Long C, Zhou H, Wang H, Sun X. The split Renilla luciferase complementation assay is useful for identifying the interaction of Epstein-Barr virus protein kinase BGLF4 and a heat shock protein Hsp90, Acta Virologica, 2016, 60: 62-70.

[7] Wang C, Wang J, Guo W,Long C, Wang H, Sun X.Amino acids essential for the interaction between cellular heat shock protein 90 and a Kaposi's sarcoma-associated herpesvirus-encoded protein kinase ORF36. Virol Sin. 2016, 31(6): 509-512.

[8] Wang C, Wang H, Zhang Y, Guo W,Long C, Wang J, Liu L, Sun X.Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncol Rep. 2017, 37(4): 2109-2120.

[9] Zhang Y, Wang H, Liu Y, Wang C, Wang J,Long C, Guo W, Sun X.Baicalein inhibits growth of Epstein-Barr virus-positive nasopharyngeal carcinoma by repressing the activity of EBNA1 Q-promoter. Biomed Pharmacother. 2018, 102:1003-1014.

[10] Wang H, Bu L, Wang C, Zhang Y, Zhou H, Zhang X, Guo W,Long C, Guo D, Sun X.The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70. Cell Death Dis. 2018, 9(7):734.

[11] Zhou H, Liu Y, Wang C, Liu L, Wang H, Zhang Y,Long C, Sun X.Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells. J Exp Clin Cancer Res. 2018, 37(1):192.

[12] Xu XF, Gao F, Wang JJ,Long C, Chen X, Tao L, Yang L, Ding L, Ji Y.BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway. Cancer Cell Int. 2019, 19:133.