一、简介

汤琪云，医学博士、教授、二级主任医师、博士生导师、博士后合作导师，南京医科大学第一附属医院老年消化科主任，江苏省神经内分泌肿瘤诊治中心主任、南京医科大学神经内分泌肿瘤研究所所长。

（1）医疗：致力于消化内镜、消化道早癌、神经内分泌肿瘤、炎症性肠病及肝脏疾病等领域的研究，从基础、临床、产业转化等方面深入探索，促进江苏省神经内分泌肿瘤的规范诊治。于2018年牵头成立了江苏省神经内分泌肿瘤诊治中心，牵头先后在南通大学、苏州大学、扬州大学、徐州医科大学等附属医院及新疆伊犁州友谊医院成立分中心，牵头成立了中国研究型医院学会消化外科专业委员会神经内分泌肿瘤学组等。2018年，于南京医科大学第一附属医院开设神经内分泌肿瘤专病门诊、专家门诊、多学科联合门诊及专病病房，为华东地区首家神经内分泌肿瘤独立病区。年诊治罕见神经内分泌肿瘤病例1000例以上。主译《胃肠胰和胸部神经内分泌肿瘤手册》，为国内第一本关于神经内分泌肿瘤的工具书。

在临床工作方面，开展四级手术如内镜黏膜下剥离术年均手术量达500-1000例，以第一完成人身份完成的“直肠神经内分泌肿瘤的内镜诊治”和“基于内镜和影像的中晚期消化系统神经内分泌肿瘤综合诊疗体系的构建”项目荣获2016年和2021年“江苏省医疗新技术引进奖一等奖”。

（2）教育：每年培养硕士、博士研究生6-8名，现有在读博士后6人。

（3）科研：申请人在基础研究方面，针对国内对神经内分泌肿瘤处于起步阶段的现状，重视其发病机制、耐药机制及新型药物靶点、新型智能靶向药物递送体系的研究，发表该领域相关高质量论文60余篇，为其深入基础研究迈出第一步（详见下文第二、三部分）。

二、主持的课题

三、英文文章：近三年发表32篇SCI文章，总影响因子超过200分。

1. 2020.03"Li X, Yu N, Li J, Bai J, Ding D,Tang Q, Xu H. Novel ""Carrier-Free"" Nanofiber Codelivery Systems with the Synergistic Antitumor Effect of Paclitaxel and Tetrandrine through the Enhancement of Mitochondrial Apoptosis. ACS Appl Mater Interfaces. 2020 Mar 4;12(9):10096-10106.共通讯

2. 2020.07"Hu P, Bai J, Liu M, Xue J, Chen T, Li R, Kuai X, Zhao H, Li X, Tian Y, Sun W, Xiong Y,Tang Q. Trends of incidence and prognosis of gastric neuroendocrine neoplasms: a study based on SEER and our multicenter research. Gastric Cancer. 2020 Jul;23(4):591-599.通讯

3. 2021.01Wu J , Ding W , Han G , You W , Gao W , Shen H , Tang J ,Tang Q, Wang X . Nuclear delivery of dual anti-cancer drugs by molecular self-assembly. Biomater Sci. 2021 Jan 5;9(1):116-123.共通讯

4. 2021.03Kan J, Tian Y, Shao Y, Xu H, Li X,Tang Q. Role of the ratio of NSE serum concentration in evaluating the therapeutic effect on metastatic neuroendocrine neoplasms of the liver. Tumori. 2021 Mar 24:3008916211002272.通讯

5. 2021.05"Xue J, Bai J, Long Q, Wei Y, Pan J, Li X,Tang Q. TCF-3-mediated transcription of lncRNA HNF1A-AS1 targeting oncostatin M expression inhibits epithelial-mesenchymal transition via TGFβsignaling in gastroenteropancreatic neuroendocrine neoplasms. Aging (Albany NY). 2021 May 25;13(10):14065-14077.通讯

6. 2021.06"Gao H, Gao Z, Jiao D, Zhang J, Li X,Tang Q, Shi Y, Ding D. Boosting Room Temperature Phosphorescence Performance by Alkyl Modification for Intravital Orthotopic Lung Tumor Imaging. Small. 2021 Jun;17(22):e2005449.共通讯

7. 2021.07Di W, Zhang W, Zhu B, Li X,Tang Q, Zhou Y. Colorectal cancer prompted adipose tissue browning and cancer cachexia through transferring exosomal miR-146b-5p. J Cell Physiol.2021 Jul;236(7):5399-5410.共通讯

8. 2021.08Xu R, Zhou B, Hu P, Xue B, Gu D, Li X,Tang Q. Development and validation of prognostic nomograms for patients with colon neuroendocrine neoplasms. World J Surg Oncol. 2021 Aug 7;19(1):233.通讯

9. 2021.09Song J, Zhang S, Sun Y, Gu J, Ye Z, Sun X,Tang Q. A Radioresponse-Related lncRNA Biomarker Signature for Risk Classification and Prognosis Prediction in Non-Small-Cell Lung Cancer. J Oncol. 2021 Sep 21;2021:4338838.通讯

10. 2021.10"Liang Y, Gong H, Li Y, Lu Y, Wu X, Zhang X, Ding D, Tang X,Tang Q. Aggregation-Induced Emission-Based Vaccine Improves Potential Antitumor Immunotherapy. J Biomed Nanotechnol. 2021 Oct 1;17(10):2053-2061.共通讯

11. 2022.03Yan L, Xu Y, Pan J, Bai J, Long Q, He N, Hu P, Liu M, Ji H, Li X,Tang Q. Prognostic Evaluation of Patients with Rectal Neuroendocrine Neoplasms and Hepatic Metastases: A SEER Database Analysis. J Oncol. 2022 Mar 26;2022:2451282.通讯

12. 2022.04"Fu J, Qiu F, Stolniceanu CR, Yu F, Zang S, Xiang Y, Huang Y, Matovic M, Stefanescu C,Tang Q, Wang F. Combined use of 177 Lu-DOTATATE peptide receptor radionuclide therapy and fluzoparib for treatment of well-differentiated neuroendocrine tumors: A preclinical study. J Neuroendocrinol. 2022 Apr;34(4):e13109.共通讯

13. 2022.05"Xue B, Zhu G, Xu R,Tang Q. Diagnosis and treatment of small intestinal neuroendocrine neoplasm by double balloon enteroscopy combined with laparoscopy: a case report. Rev Esp Enferm Dig. 2022 May 31.通讯

14. 2022.07Xu Y, Yan L, Chen T, Hu P, Bai J, Ye T, Long Q,Tang Q. Prognosis of patients with poorly differentiated gastric neuroendocrine neoplasms: a multi-center study in China. Future Oncol. 2022 Jul;18(22):2465-2473.通讯

15. 2022.08Zhang Z, Ji Y, Hu N, Yu Q, Zhang X, Li J, Wu F, Xu H,Tang Q, Li X. Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment. Asian J Pharm Sci. 2022 Aug;17(5):751-766.共通讯

16. 2022.09Xu R, Jiao D, Long Q, Li X, Shan K, Kong X, Ou H, Ding D,Tang Q. Highly bright aggregation-induced emission nanodots for precise photoacoustic/NIR-II fluorescence imaging-guided resection of neuroendocrine neoplasms and sentinel lymph nodes. Biomaterials. 2022 Sep 2;289:121780.共通讯

17. 2022.09Yan L, Chen X, Bian Z, Gu C, Ji H, Chen L, Xu H,Tang Q. A ferroptosis associated gene signature for predicting prognosis and immune responses in patients with colorectal carcinoma. Front Genet. 2022 Sep 8;13:971364.共通讯

18. 2023.02Sun K, Xu R, Xue B, Liu P, Bai J, Tian Y, Li X,Tang Q. ROS-responsive ADPH nanoparticles for image-guided surgery. Front Chem. 2023 Feb 8;11:1121957.通讯

19. 2023.03Chen J, Ye M, Bai J, Hu C, Lu F, Gu D, Yu P,Tang Q. Novel insights into the interplay between m6A modification and programmed cell death in cancer. Int J Biol Sci. 2023 Mar 13;19(6):1748-1763.通讯

20. 2023.05Ye M, Lu F, Chen J, Yu P, Xu Y, He N, Hu C, Zhong Y, Yan L, Gu D, Xu L, Bai J, Tian Y,Tang Q. Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway. J Cancer. 2023 May 21;14(8):1458-1469.通讯

21. 2023.06Tian Y, Xue C, Li X, Bai J, Xiao Z, He Q, Kan J, Zhu G,Tang Q. Efficacy and safety of modified endoscopic submucosal tunnel dissection for superficial esophageal circumferential lesions. Dis Esophagus. 2023 Jun 2:doad035.通讯

22. 2023.06Lu F, Ye M, Hu C, Chen J, Yan L, Gu D, Xu L, Tian Y, Bai J,Tang Q. FABP5 regulates lipid metabolism to facilitate pancreatic neuroendocrine neoplasms progression via FASN mediated Wnt/β-catenin pathway. Cancer Sci.通讯

23. 2023.06Ye M, Hu C, Chen T, Yu P, Chen J, Lu F, Xu L, Zhong Y, Yan L, Kan J, Bai J, Li X, Tian Y,Tang Q. FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression. Int J Biol Sci. 2023 Jun 12;19(10):3115-3127.通讯

24. 2023.07Ye M, Gao R, Chen S, Bai J, Chen J, Lu F, Gu D, Shi X, Yu P, Tian Y,Tang Q, Dong K. FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5. Commun Biol. 2023 Jul 12;6(1):714.共通讯

25. 2023.07Hu C, Ye M, Bai J, Liu P, Lu F, Chen J, Yu P, Chen T, Shi X,Tang Q. Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial-mesenchymal transition. Cancer Cell Int. 2023 Jul 5;23(1):131.通讯

26. 2023.08Ye M, Chen J, Yu P, Hu C, Wang B, Bao J, Lu F, Zhong Y, Yan L, Kan J, Bai J, Tian Y,Tang Q. WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA-mediated by YTHDC1 to promote colorectal cancer development. FASEB J. 2023 Aug;37(8):e23090.通讯

27. 2023.08Bai J, Song J, Zhang Y, Li X, Yan L, Hu P,Tang Q. Transcatheter arterial embolization in patients with neuroendocrine neoplasms related to liver metastasis with different blood supplies. Cancer Med. 2023 Aug 17.通讯

28. 2023.08Ye M, Chen J, Lu F, Zhao M, Wu S, Hu C, Yu P, Kan J, Bai J, Tian Y,Tang Q. Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer. Cell Biosci. 2023 Aug 14;13(1):148.通讯

29. 2023.09Lu F, Ye M, Hu C, Chen J, Yan L, Gu D, Xu L, Tian Y, Bai J,Tang Q. FABP5 regulates lipid metabolism to facilitate pancreatic neuroendocrine neoplasms progression via FASN mediated Wnt/β-catenin pathway. Cancer Sci. 2023 Sep;114(9):3553-3567.通讯

30. 2023.09Bai J, Song J, Zhang Y, Li X, Yan L, Hu P,Tang Q. Transcatheter arterial embolization in patients with neuroendocrine neoplasms related to liver metastasis with different blood supplies. Cancer Med. 2023 Sep;12(18):18578-18587.通讯

31. 2023.10Tian Y, Xue C, Li X, Bai J, Xiao Z, He Q, Kan J, Zhu G,Tang Q. Efficacy and safety of modified endoscopic submucosal tunnel dissection for superficial esophageal circumferential lesions. Dis Esophagus. 2023 Oct 27;36(11):doad035.通讯

32. 2023.10Chen J, Ye M, Bai J, Gong Z, Yan L, Gu D, Hu C, Lu F, Yu P, Xu L, Wang Y, Tian Y,Tang Q. ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner. J Transl Med. 2023 Oct 19;21(1):741.通讯

四、中文文章：近三年发表22篇文章。

1. 2020.04杨晓玉,柏建安,孙诚,汤琪云.下调转化生长因子β激活激酶1抑制胰腺神经内分泌肿瘤转移和侵袭[J].胃肠病学和肝病学杂志,2020,29(04):406-410.通讯

2. 2020.04熊羽佳,刘小玉,成翠娥,陈晨,孙逸斌,谈辰欢,刘义婷,冯吉,马亦凡,史冬涛,李锐,汤琪云.原发性胃神经内分泌肿瘤的临床特点、病理及预后分析[J].中华内科杂志,2020(04):297-298-299-300-301-302.共通讯

3. 2020.06熊羽佳,成翠娥,李锐,汤琪云.胃神经内分泌肿瘤148例临床病理特征和预后分析[J].中华消化杂志,2020,40(06):407-410.通讯

4. 2020.10张阳阳,汤琪云,张一清.21例老年直肠神经内分泌肿瘤病人的内镜下治疗及康复质量分析[J].实用老年医学,2020,34(10):1027-1029+1033.

5. 2021.02胡平,汤琪云.胃肠胰神经内分泌肿瘤肝转移的非手术治疗进展[J].胃肠病学和肝病学杂志,2021,30(2):212-216.通讯

6. 2021.06薛冰艳,田野,朱国琴,李晓林,汤琪云.内镜黏膜下剥离术治疗浅表食管癌368例临床分析[J].中华消化杂志,2021,41(06):379-384.通讯

7. 2021.07胃肠胰神经内分泌肿瘤的内镜诊治进展.薛冰艳;柏建安;朱国琴;李晓林;周逸婵;徐瑞彤;顾丹阳;田野;范志宁;汤琪云.中华消化内镜杂志,2021(07)通讯

8. 2021.10薛冰艳,史青林,徐瑞彤,汤琪云,朱国琴.以多浆膜腔积液为首发表现的老年多发性骨髓瘤1例[J].实用老年医学,2021,35(10):1107-1108.共通讯

9. 2021.12胡平,柏建安,田野,刘敏,汤琪云.炎症性肠病合并神经内分泌肿瘤的临床特征分析[J].中华消化内镜杂志,2021,38(12):1021-1025.通讯

10. 2022.06陈挑调,柏建安,叶木杰,严丽军,潘佳玲汤琪云.(2022).奥曲肽联合黄芩素抑制胰腺神经内分泌肿瘤细胞增殖和迁移.现代生物医学进展(12),2201-2207.通讯

11. 2022.06潘佳玲,柏建安,严丽军,陈挑调汤琪云.(2022).长链非编码RNA n336928对胃肠胰神经内分泌肿瘤细胞增殖及迁移的影响.现代生物医学进展(11),2001-2007.通讯

12. 2022.07汤琪云,王峰,刘云等.消化系统神经内分泌肿瘤诊治难点和热点[J].中华医学杂志,2022,102(14):977-981.一作

13. 2022.07顾丹阳,付麒,薛冰艳,阚敬保,柏建安,汤琪云.多发性内分泌腺瘤1型相关型与散发型胰腺神经内分泌肿瘤临床特征比较[J].中华医学杂志,2022,102(14):1014-1019.通讯

14. 2022.07柏建安,田野,李晓林,邵耘,许海尘,朱国琴,周逸婵,汤琪云.神经内分泌肿瘤非手术治疗研究进展[J].中华医学杂志,2022,102(14):1047-1051.通讯

15. 2022.07徐艳玲,宋词,胡平,田野,阚敬保,胡志斌,汤琪云.神经内分泌肿瘤的流行现状[J].中华医学杂志,2022,102(14):1042-1046.通讯

16. 2022.07胡平,刘敏,李晓林,柏建安,田野,朱国琴,汤琪云.罕见结肠双向分化癌1例[J].中华医学杂志,2022,102(14):1039-1041.通讯

17. 2022.07姚晓晨,张川,臧士明,汤琪云,王峰等.肽受体放射性核素治疗转移性神经内分泌肿瘤的效果和安全性[J].中华医学杂志,2022,102(14):1034-1038.共同通讯

18. 2022.09郭天灏,洪盛威,柏建安,程海波汤琪云.(2022).基于系统药理学方法探讨六君子汤治疗胃肠胰神经内分泌肿瘤的作用机制.中医肿瘤学杂志(05),35-42+59.共同通讯

19. 2022.12改良多隧道法内镜黏膜下剥离术治疗长度大于8 cm食管全周浅表癌的临床研究.田野;杜观祥;阚敬保;刘敏;柏建安;刘禹;汤琪云.中华消化内镜杂志,2022(12)通讯

20. 2023.05食管全周浅表癌内镜黏膜下剥离术后长期保留胃管对食管狭窄的预防及治疗作用.田野;薛成俊;李晓敏;肖泽泉;柏建安;阚敬保;龙琴;严丽军;王燕梅;汤琪云.中华消化内镜杂志,2023(05),通讯

21. 2023.07顾丹阳,柏建安,朱国琴,薛冰艳,胡平汤琪云.(2023).多发性内分泌腺瘤1型的临床特征分析.南京医科大学学报(自然科学版)(07),981-985.通讯

22. 2023.10李晓敏,汤琪云,吴蕾,郝冉冉 柏建安.(2023).预警护理在老年糖尿病患者无痛内镜检查中的应用.中国卫生标准管理(19),190-193.通讯