曹小卫，男，1986年出生，博士，副研究员。2012年在东南大学生物医学工程专业获工学博士学位。同年9月到扬州大学医学院工作。现为Frontiers in Bioengineering and Biotechnology、Molecules等期刊客座主编、中国化学学会和中国微纳米学会高级会员、江苏省“科技副总”、江苏省“青蓝工程”优秀青年骨干教师、扬州市“绿杨金凤”优秀博士、扬州大学“拔尖人才成长计划”培养对象。主要从事光谱生物传感、免疫分析的基础问题研究、各类疾病的诊断及治疗等工作。前期构建了侧向层析试纸条、光纤、微流控芯片等生物传感器，针对miRNAs、ctDNA、酶、蛋白质进行深入的研究，也取得了一系列的研究成果。先后承担和完成了国家级、省部级课题10余项。以第一/通讯作者在Biomaterials、Biosensors & Bioelectronics、Sensors and Actuators B: Chemical、Journal of Nanobiotechnology等期刊发表SCI论文40多篇。以第一发明人获国外发明专利授权1项和国家发明专利授权3项。

曹小卫，男，1986.11，中共党员，博士，副研究员，硕士生导师。

通讯地址：江苏省扬州市邗江区江阳中路136号

办公地址：江苏省扬州大学江阳路北校区28号楼402室

E-mail：cxw19861121@163.com

主持或参与项目

1. 国家自然科学基金，青年项目，81701825，基于空心金纳米花SERS探针对非小细胞肺癌中miRNA的检测研究，2018/01-2020/12，20万元，结题，主持

2. 江苏省重点研发计划（社会发展）项目，BE2018684，基于海胆状金纳米粒子SERS-GICA核酸试纸条技术对肺癌中miRNA的检测研究，2018/07-2021/06，50万元，结题，主持

3. 江苏省高等学校自然科学基金，面上项目，17KJB416012，基于空心金纳米花SERS探针检测细胞中miRNA，2018/01-2020/12，3万元，结题，主持

4. 扬州市绿扬金风人才项目，SERS-GICA核酸试纸条对肺癌中miRNA的检测研究，2019/07-2022/06，6万元，结题，主持

5. 教育部重点实验室开发课题，基于银纳米多巴胺复合微球的SERS-ICA试纸的制备及其用于上皮性卵巢癌的早期筛查，2020/07-2022/06，5万元，结题，主持

6. 中国博士后自然科学基金，面上项目，2017M611927，空心金纳米花SERS探针的制备及其用于检测肺癌中miRNA，2017/09-2020/08，5万元，结题，主持

7. 江苏省博士后基金，1701141C，基于空心金纳米花SERS探针对细胞中miRNA的检测研，2017/09-2020/08，2万元，结题，主持

8. 横向委托课题，21081220000007（来源于江苏省食品药品监督检验研究院），食用油中氯丙烯酯含量的验证，2018/10-2019/06，5万元，结题，主持

9. 国家自然科学基金，面上项目，82072088，基于空心金纳米笼制备新型SERS-ICA诊断试纸用于宫颈癌早期诊断和高危人群筛查，2021/01-2024/12，56万元，进行，参与

10. 国家自然科学基金委员会，面上项目，82172603，PDGFR通路调控SOX2+周细胞前体细胞转化促胶质瘤进展机制研究，2022/01-2025/12，55万元，在研，参与

11. 国家自然科学基金，面上项目，81770018，基于3D生物打印构建杂化式组织工程气管的实验研究，2018/01-2020/12，55万元，结题，参与

12. 国家973计划项目，2012CB933302，基于纳米技术的肺癌早期检测研究，2012/01-2016/12，2500万元，结题，参与

13. 国家科技支撑计划项目，2007BAE42B04，魔芋葡甘聚糖规模化加工和应用的关键技术，2007/01-2011/12，100万元，结题，参与

近三年发表论文 (2021-2023)

1. Xiaowei Cao, Yingyan Gu, Zhiyue Li, Shengjie Ge, Yu Mao, Yuexing Gu, Dan Lu*. A SERS microfluidic chip for ultrasensitive and simultaneous detection of SCCA and CYFRA21-1 in serum based on Au nanobowl arrays and hybridization chain reaction. Sensors and Actuators B: Chemical, 2023, 375: 132894. (SCI一区)

2. Dawei Cao, Hechuan Lin, Ziyang Liu, Jiaji Qiu, Shengjie Ge, Weiwei Hua, Xiaowei Cao*, Yayun Qian*, Huiying Xu*, Xinzhong Zhu. PCA-TLNN-based SERS analysis platform for label-free detection and identification of cisplatin-treated gastric cancer. Sensors and Actuators B: Chemical, 2023, 375: 132903. (SCI一区)

3. Xiaowei Cao, Shengjie Ge, Miao Chen, Haiyan Mao, Ying Wang*. LoC-SERS platform integrated with signal amplification strategy towards Parkinson’s disease diagnosis. ACS Applied Materials & Interfaces, 2023, Accepted. (SCI一区)

4. Xiaowei Cao*, Shengjie Ge, Xinyu Zhou, Yu Mao, Yue Sun, Wenbo Lu, Menglin Ran. A dual-signal amplification strategy based on pump-free SERS microfluidic chip for rapid and ultrasensitive detection of non-small cell lung cancer-related circulating tumor DNA in mice serum. Biosensors and Bioelectronics, 2022, 205: 114110. (SCI一区)

5. Dawei Cao, Hechuan Lin, Ziyang Liu, Yuexing Gu, Weiwei Hua, Xiaowei Cao*, Yayun Qian*, Huiying Xu*, Xinzhong Zhu. Serum-based surface-enhanced Raman spectroscopy combined with PCA-RCKNCN for rapid and accurate identification of lung cancer. Analytica Chimica Acta, 2022, 1236: 340574. (SCI一区)

6. Xiaowei Cao*, Shengjie Ge, Weiwei Hua, Xinyu Zhou, Wenbo Lu, Yingyan Gu, Zhiyue, Yayun Qian*. A pump-free and high-throughput microfuidic chip for highly sensitive SERS assay of gastric cancer-related circulating tumor DNA via a cascade signal amplifcation strategy. Journal of Nanobiotechnology, 2022, 20: 271. (SCI一区)

7. Shengjie Ge, Guang Li, Xinyu Zhou, Yu Mao, Yingyan Gu, Zhiyue Li, Yuexing Gu, Xiaowei Cao*. Pump-free microfluidic chip based laryngeal squamous cell carcinoma-related microRNAs detection through the combination of surface-enhanced Raman scattering techniques and catalytic hairpin assembly amplification. Talanta, 2022, 245: 123478. (SCI一区)

8. Xiaowei Cao*, Yu Mao, Yuexing Gu, Shengjie Ge, Wenbo Lu, Yingyan Gu, Zhiyue Li. Highly sensitive and simultaneous detection of ctDNAs related to non-small cell lung cancer in serum using a catalytic hairpin assembly strategy in a SERS microfluidic chip. Journal of Materials Chemistry B, 2022,10: 6194-6206. (SCI二区)

9. Yuexing Gu, Dawei Cao, Yu Mao, Shengjie Ge, Zhiyue Li, Yingyan Gu, Yue Sun, Li Li*, Xiaowei Cao*.A SERS microfluidic chip based on hpDNA-functioned Au-Ag nanobowl array for efficient simultaneous detection of non-small cell lung cancer-related microRNAs. Microchemical Journal, 2022, 182: 107836. (SCI二区)

10. Dan Lu, Zhiyue Li, Yingyan Gu, Shengjie Ge, Yu Mao, Yuexing Gu, Xiaowei Cao*. A novel SERS biosensor for ultrasensitive detection of HPV-E7 and OPN based on a cascade signal amplification strategy of catalytic hairpin assembly and hybridization chain reaction. Materials Chemistry Frontiers, 2022, 6: 1331-1343. (SCI二区)

11. Yingyan Gu, Zhiyue Li, Shengjie Ge, Yu Mao, Yuexing Gu, Xiaowei Cao*, Dan Lu*. A microfluidic chip using Au@SiO₂ array-based highly SERS-active substrates for ultrasensitive detection of dual cervical cancer-related biomarkers. Analytical and Bioanalytical Chemistry, 2022, 414(26): 7659-7673. (SCI二区)

12. Zhiyue Li, Yingyan Gu, Shengjie Ge, Yu Mao, Yuexing Gu, Xiaowei Cao*, Lu, Dan*. An aptamer-based SERS-LFA biosensor with multiple channels for the ultrasensitive simultaneous detection of serum VEGF and osteopontin in cervical cancer patients. New Journal of Chemistry, 2022, 46(43): 20629-20642. (SCI三区)

13. Xiaowei Cao*, Yue Sun, Yu Mao, Menglin Ran, Yifan Liu, Dan Lu*, Caili Bi. Rapid and sensitive detection of dual lung cancer-associated miRNA biomarkers by a novel SERS-LFA strip coupling with catalytic hairpin assembly signal amplification. Journal of Materials Chemistry C, 2021, 9: 3661-3671. (SCI二区)

14. Xinyu Zhou, Shengjie Ge, Yue Sun, Menglin Ran, Yifan Liu, Yu Mao, Xiaowei Cao*. Highly sensitive SERS assay of genetically modified organisms in maize via a nanoflower substrate coupled with hybridization chain reaction amplification. New Journal of Chemistry, 2021, 45: 20586-20595. (SCI三区)

15. Xiaowei Cao*, Qilong Song, Yue Sun, Yu Mao,Wenbo Lu, Li Li*. A SERS-LFA biosensor combined with aptamer recognition for simultaneous detection of thrombin and PDGF-BB in prostate cancer plasma. Nanotechnology, 2021, 32: 445101. (SCI三区)

16. Shengjie Ge, Menglin Ran, Yu Mao, Yue Sun, Xinyu Zhou, Li Li*, Xiaowei Cao*. A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density “hot spot” SERS substrate and rolling circle amplification strategy. Analyst, 2021, 146: 5326-5336. (SCI二区)

17. Yu Mao, Yue Sun, Jin Xue, Wenbo Lu, Xiaowei Cao*. Ultra-sensitive and high efficiency detection of multiple non-small cell lung cancer-related miRNAs on a single test line in catalytic hairpin assembly-based SERS-LFA strip. Analytica Chimica Acta, 2021, 1178: 338800. (SCI一区)

18. Yue Sun, Youwei Wang, Wenbo Lu, Chang Liu, Shengjie Ge, Xinyu Zhou, Caili Bi*, Xiaowei Cao*. A novel surface-enhanced Raman scattering probe based on Au nanoboxes for dynamic monitoring of caspase-3 during cervical cancer cell apoptosis. Journal of Materials Chemistry B, 2021, 9: 381-391. (SCI二区)

19. Jin Xue, Xiaowei Cao*, Yifan Liu*, Min Wang. Preparation of Paper Hollow Gold Nanocage SERS Sensor and Its Rapid and Highly Sensitive Detection for miRNAs in Sputum of Patients with Non-small Cell Lung Cancer. Chemical Journal Chinese Universities-Chinese, 2021, 8: 2393-2402. (SCI四区)

20. Yifan Liu, Menglin Ran, Yue Sun, Yongxin Fan, Jinghan Wang, Xiaowei Cao*, Dan Lu*. A sandwich SERS immunoassay platform based on a single-layer Au-Ag nanobox array substrate for simultaneous detection of SCCA and survivin in serum of patients with cervical lesions. RSC Advances, 2021, 11(58): 36734-36747. (SCI三区)

近三年授权发明专利 (2021-2023)

1. 曹小卫, 孙悦, 毛宇, 用于检测肺癌标志物的金纳米笼SERS传感器及其制备方法, 2022-02-01, 中国, CN202110436674.6

2. 曹小卫, 王振雨, 李巍, 用于检测肺癌标志物miR-196a的金银纳米线SERS传感器的制备方法及传感器, 2021-07-16, 中国, CN201910263815.1

3. 李里, 周炜, 曹小卫, 李伟, 于晓文, SERS基底、SERS微流控芯片及制备方法和应用, 2022-12-30, 中国, CN202210355238.0