一、基本信息

贾筱琴，女，1971年9月出生，医学博士，副教授，硕士生导师，扬州大学医学院，邮箱：xqjia@yzu.edu.cn。

二、教育经历

1990.9-1995.7,华西医科大学,临床医学系5年制，学士

2001.9-2004.7,扬州大学,兽医学院，实验动物学,硕士

2007.9-2010.7,南京医科大学,基础医学院，病理学与病理生理学，博士

三、研究方向

主要从事肿瘤免疫和代谢相关研究

四、承担项目

1.国家自然科学基金面上项目，GPIHBP1基于能量代谢调控EMT发生和TAM分化促进结直肠癌转移的作用及机制，82272809，2023 01- 2026.12，52万，主持

2.国家自然科学基金面上项目，Apoc3基于能量代谢调控CD8+T和NK细胞的活性及其分子机制，81873867，2019.01-2022.12，57万元，主持。

3.国家自然科学基金面上项目，MiR-16对肝癌巨噬细胞表型和功能的影响及分子机制，81273214，2013.01-2016.12，70万元，主持

4.主持江苏省高校自然科学研究面上项目，miR-148a在肝癌转移中的作用及分子机理研究，2010.09- 2012.12，主持。

五、代表性论著

1. Xiangyu Hu,Shizhen Ding,Guotao Lu, Zhijie Lin , Liting Liao,Weiming Xiao , Yanbing Ding,Yu Zhang,Zhengbing Wang ,Weijuan Gong,Xiaoqin Jia .Apolipoprotein C‑III itself stimulates the Syk/cPLA2‑induced inflammasome activation of macrophage to boost anti‑tumor activity of CD8 + T cell. Cancer Immunol Immunother . 2023 Oct 18. doi: 10.1007/s00262-023-03547-8.

2. Linghui Jia,Liting Liao,Yongshuai Jiang,Xiangyu Hu,Guotao Lu,Weiming Xiao,Weijuan Gong,Xiaoqin Jia,Jia Xiaoqin. Low-dose adropin stimulates inflammasome activation of macrophage via mitochondrial ROS involved in colorectal cancer progression. BMC Cancer . 2023 Oct 30;23(1):1042.

3. Xiangyu Hu*, Xiaoqin Jia*, Cong Xu , Yingying Wei, Zhengbing Wang , George Liu , Qiang You , Guotao Lu, Weijuan Gong. Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells. Metabolism,2021 Jul;120:154800.

4. Xiaoqin Jia, Yingying Wei, Xin Miao, Tao Zhu, Xiangyu Hu, Zhijie Lin, Weiming Xiao, Yu Zhang, Zhengbing Wang, Weijuan Gong. Deficiency of miR-15a/16 upregulates NKG2D in CD8 + T cells to exacerbate dextran sulfate sodium-induced colitis. Biochem Biophys Res Commun,2021 May 21;554:114-122.

5. Tao Zhu, Zhijie Lin, Sen Han, Yingying Wei, Guotao Lu, Yu Zhang, Weiming Xiao, Zhengbing Wang, Xiaoqin Jia# , Weijuan Gong#. Low miR-16 expression induces regulatory CD4 + NKG2D + T cells involved in colorectal cancer progression. Am J Cancer Res,2021 Apr 15;11(4):1540-1556.

6. Xiaoqin Jia, Hao Liu, Chong Xu, Sen Han, Yating Shen, Xin Miao, Xiangyu Hu, Zhijie Lin, Li Qian, Zhengbing Wang, Weijuan Gong. MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19+ TIM‐1+ cells in tumor microenvironment. J Cell Mol Med,2019 Feb;23(2):1343-1353.

7. Jia X, Hu X, Han S, Miao X, Liu H, Li X, Lin Z, Wang Z*, Gong W*. Increased M1 macrophages in young miR-15a/16(-/-) mice with tumour grafts or dextran sulphate sodium-induced colitis. Scand J Immunol. 2018 ;88(3):e12703.

8. Jia X, Li X, Shen Y, Miao J, Liu H, Li G, Wang Z. MiR-16 regulates mouse peritoneal macrophage polarization and affects T-cell activation. J Cell Mol Med.2016 ;20(10):1898-1907.

9. Jia XQ#, Zhang S#, Zhu HJ, Wang W, Zhu JH, Wang XD*, Qiang JF*. Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer. Transl Oncol. 2016 ;9(3):191-196.

六、获奖情况

1.中国商业联合会科学技术奖二等奖（2019）

2.江苏省医学会科技进步奖三等奖（2022）