On May 24th, Professor Yang Hua, a Changjiang Scholar appointed by the Ministry of Education, recipient of the National Outstanding Youth Fund, and a National Young Qihuang Scholar, as well as the Secretary of the Party Committee and Executive Deputy Director of the National Key Laboratory of Multitargeted Natural Drugs at China Pharmaceutical University, delivered an academic lecture titled "Analysis and Translational Application of Complex Component Group Action Patterns of Traditional Chinese Medicine" at the forum. The lecture was chaired by Professor Liu Liang, Secretary of the Party Branch of the School of Pharmacy, and attended by faculty and students from the School of Medicine.
Professor Yang addressed the challenges posed by the complexity of chemical components in traditional Chinese medicine, diverse metabolism in the body, and unclear effective substances. He innovatively proposed that a group of components in traditional Chinese medicine formulations may represent the therapeutic efficacy of the original formula, interact at key stages of disease occurrence and development, and coordinate to exert pharmacological activities. Professor Yang focused on the structural analysis, functional analysis, and target analysis of traditional Chinese medicine components. He pointed out that a single component obtained from traditional Chinese medicine is unlikely to represent the overall efficacy of the formulation. Through years of research, he found that by analyzing the structure and activity of active components in complex formulations, it is possible to simplify formulations containing dozens of substances into a certain number of component combinations. He developed a research technology system for "discovery and action mechanism of multi-component combinations derived from complex traditional Chinese medicine systems" and used big data analysis to identify effective component combinations in a series of traditional Chinese medicines and formulations such as Ginkgo biloba leaves, Danshen decoction, and Ginseng-Aconite Decoction. He explored integrated action modes such as "overall correction" of multi-component traditional Chinese medicine. These achievements have been successfully translated into practical applications.
After the lecture, Professor Yang engaged in in-depth discussions and lively interactive exchanges with the attending faculty and students on topics such as complex component group action patterns and integrated action mechanisms of traditional Chinese medicine.
